Reward anticipation and trait anhedonia: An electrophysiological investigation in subjects with schizophrenia
| Autor: | J. Ford, G.M. Plescia, Silvana Galderisi, Paola Bucci, Armida Mucci, V. Montefusco, A. Vignapiano |
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| Přispěvatelé: | Vignapiano, A, Mucci, Armida, Ford, J., Montefusco, V., Plescia, G. M., Bucci, Paola, Galderisi, Silvana |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Event-related potential Anhedonia Reward anticipation media_common.quotation_subject Pleasure Young Adult 03 medical and health sciences 0302 clinical medicine Reward Physiology (medical) Schizophrenic Psychology Reaction Time medicine Humans Avolition Valence (psychology) media_common P3 Anticipation Psychological Sensory Systems 030227 psychiatry Incentive Neurology Trait Schizophrenia Female Neurology (clinical) medicine.symptom Psychology Photic Stimulation psychological phenomena and processes 030217 neurology & neurosurgery Clinical psychology Cognitive psychology |
| Popis: | Objective Investigate impairment of reward anticipation in subjects with schizophrenia (SCZ) and its association with negative symptom dimensions and hedonic experience. Methods Event-related potentials (ERPs) were recorded, in thirty SCZ and twenty-three matched healthy controls (HC), during a "Monetary Incentive Delay" task in which reward and loss cues (incentive cues of positive and negative value) of different magnitude, as well as neutral cues were presented. Assessments: anticipatory and consummatory pleasure, trait anhedonia and motivation in all subjects; avolition and expressive deficit in SCZ. Results SCZ had lower motivation but comparable hedonic experience with respect to HC. In HC, during reward anticipation, the early P3 was larger for large magnitude incentives, irrespective of their valence, while the late P3 was larger for large reward. In SCZ, early P3 did not discriminate the incentive magnitude and the late P3 was larger for large loss. Early P3 amplitude for large magnitude incentives was inversely related to trait social anhedonia but not to negative symptoms dimensions. Conclusions SCZ are unable to integrate the incentive magnitude and reward value of future events in the context of their ongoing task. P3 abnormalities are associated with trait anhedonia, but not with negative symptoms dimensions. Significance In line with recent studies, our findings indicate that anhedonia and avolition are partially independent constructs. |
| Databáze: | OpenAIRE |
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