Acute Oxalate Nephropathy Causing Late Renal Transplant Dysfunction Due to Enteric Hyperoxaluria
| Autor: | A C Rankin, Stephen B. Walsh, M P Owen, M A Mansell, Shaun A. Summers |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Calcium oxalate Gastroenterology Nephropathy chemistry.chemical_compound Renal Dialysis Internal medicine medicine Humans Immunology and Allergy Pharmacology (medical) Aged Hyperoxaluria Transplantation Kidney Calcium Oxalate business.industry Acute Kidney Injury medicine.disease Kidney Transplantation Fat malabsorption Surgery Treatment Outcome surgical procedures operative medicine.anatomical_structure chemistry Acute Disease Exocrine Pancreatic Insufficiency Hemodialysis business Enteric Hyperoxaluria Kidney disease |
| Zdroj: | American Journal of Transplantation. 8:1755-1758 |
| ISSN: | 1600-6135 |
| DOI: | 10.1111/j.1600-6143.2008.02288.x |
| Popis: | Calcium oxalate (CaOx) deposition in the renal allograft is an under recognized and important cause of acute tubular injury and early allograft dysfunction. We present a case of late transplant dysfunction due to acute oxalate nephropathy. The patient presented with diarrhea and deteriorating graft function, and a diagnosis of enteric hyperoxaluria secondary to pancreatic insufficiency was made. This had occurred, as the patient had been noncompliant with his pancreatic enzyme replacement therapy. Treatment to reduce his circulating oxalate load was initiated, including twice-daily hemodialysis, low fat and oxalate diet and appropriate administration of pancreatic enzyme supplements. Graft function subsequently recovered. The possibility of fat malabsorption leading to enteric hyperoxaluria should be considered in renal graft recipients presenting with loose stools and graft dysfunction. |
| Databáze: | OpenAIRE |
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