Screening for Stimulant Use in Adult Emergency Department Seizure Patients
| Autor: | Mark T. Steele, Mark Steele, Ellen J. Westdorp, Alex G. Garza, O. John Ma, David K. Roberts, William A. Watson |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Health Toxicology and Mutagenesis medicine.medical_treatment Amphetamine-Related Disorders Toxicology Immunoenzyme Techniques Cocaine-Related Disorders chemistry.chemical_compound Cocaine Seizures Convulsion Humans Mass Screening Medicine Single-Blind Method Prospective Studies Amphetamine Prospective cohort study Mass screening Missouri business.industry Emergency department Middle Aged Stimulant chemistry Anesthesia Benzoylecgonine Sample collection medicine.symptom Emergency Service Hospital business medicine.drug |
| Zdroj: | Journal of Toxicology: Clinical Toxicology. 38:609-613 |
| ISSN: | 0731-3810 |
| DOI: | 10.1081/clt-100102009 |
| Popis: | The objective of this study was to determine the prevalence of positive plasma drug screening for cocaine or amphetamine in adult emergency department seizure patients.This prospective study evaluated consecutive eligible seizure patients who had a plasma sample collected as part of their clinical evaluation. Plasma was tested for amphetamine and the cocaine metabolite benzoylecgonine using enzyme-mediated immunoassay methodology. Plasma samples with benzoylecgonine greater than 150 ng/mL or an amphetamine greater than 500 ng/mL were defined as positive. Patient demographics, history of underlying drug or alcohol-related seizure disorder, estimated time from seizure to sample collection, history or suspicion of cocaine or amphetamine abuse, results of clinical urine testing for drugs of abuse, and assay results were recorded without patient identifiers.Fourteen of 248 (5.6%, 95% CI 2.7%-8.5%) plasma samples were positive by immunoassay testing for benzoylecgonine and no samples (0%, 95% CI 0-1.2%) were positive for amphetamine. Positive test results were more common in patient visits where there was a history or suspicion of cocaine or amphetamine abuse (p0.0005).During this study period, routine plasma screening for cocaine and amphetamines in adult seizure patients had a low yield. As a result, routine plasma screening would yield few cases of stimulant drug in which there was neither a history nor suspicion of drug abuse in this population. |
| Databáze: | OpenAIRE |
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