Inhibitory phlorotannins from the edible brown algaecklonia stolonifera on total reactive oxygen species (ROS) generation
| Autor: | Jiyoung Kim, Hye Sook Kang, Hae Young Chung, Jae Sue Choi, Hyun Ah Jung, Byeng Wha Son |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Phloroglucinol In Vitro Techniques Dioxins Kidney Phaeophyta Antioxidants chemistry.chemical_compound Drug Discovery Animals Laminariaceae Rats Wistar biology Eckol Organic Chemistry Kidney metabolism Fluoresceins biology.organism_classification Rats Dieckol Stolonifera Brown algae Spectrometry Fluorescence Biochemistry chemistry Molecular Medicine Spectrophotometry Ultraviolet Chromatography Thin Layer Ecklonia stolonifera Reactive Oxygen Species Oxidation-Reduction |
| Zdroj: | Archives of Pharmacal Research. 27:194-198 |
| ISSN: | 1976-3786 0253-6269 |
| Popis: | Reactive oxygen species (ROS) play an important role in the pathogenesis of many human degenerative diseases such as cancer, aging, arteriosclerosis, and rheumatism. Much attention has been focused on the development of safe and effective antioxidants. To discover sources of antioxidative activity in marine algae, extracts from 17 kinds of seaweed were screened for their inhibitory effect on total ROS generation in kidney homogenate using 2',7'-dichlorofluorescein diacetate (DCFH-DA). ROS inhibition was seen in three species: Ulva pertusa, Symphyocladia latiuscula, and Ecklonia stolonifera. At a final concentration of 25 microg/mL, U. pertusa inhibited 85.65+/-20.28% of total ROS generation, S. latiscula caused 50.63+/-0.09% inhibitory, and the Ecklonia species was 44.30+/-7.33% inhibition. E. stolonifera Okamura (Laminariaceae), which belongs to the brown algae, has been further investigated because it is commonly used as a foodstuff in Korea. Five compounds, phloroglucinol (1), eckstolonol (2), eckol (3), phlorofucofuroeckol A (4), and dieckol (5), isolated from the ethyl acetate soluble fraction of the methanolic extract of E. stolonifera inhibited total ROS generation. |
| Databáze: | OpenAIRE |
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