Biochemical mechanisms of stress-induced impairment of rat T cell mitogenesis
| Autor: | Christine Lackner, Marvin Stein, Anthony C. Santucci, James P. Halper, Robert L. Trestman, Andrew H. Miller |
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| Rok vydání: | 1991 |
| Předmět: |
Male
Restraint Physical medicine.medical_specialty T cell T-Lymphocytes Immunology chemistry.chemical_element Stimulation Calcium Biology Lymphocyte Activation Phosphatidylinositols Calcium in biology chemistry.chemical_compound Stress Physiological Internal medicine medicine Immunology and Allergy Animals Protein kinase C Analysis of Variance Electroshock Rats Inbred Strains Rats medicine.anatomical_structure Endocrinology Neurology chemistry Concanavalin A Tetradecanoylphorbol Acetate Ionomycin biology.protein Interleukin-2 Neurology (clinical) |
| Zdroj: | Journal of neuroimmunology. 32(3) |
| ISSN: | 0165-5728 |
| Popis: | Splenic mononuclear cells isolated from rats exposed to two brief stressors (5 min of restraint or 2 min of footshock) showed a diminished response to the T cell mitogens, concanavalin A and phytohemagglutinin. Cells from these stressed animals also exhibited a diminished response to stimulation with the phorbol ester, tetradecanoylphorbol acetate (TPA), and/or the calcium ionophore, ionomycin. Since stimulation with these latter two agents mimics early signals generated by mitogen surface receptor binding including increased intracellular calcium and protein kinase C activation, the data indicate that stress-related defects in T cell proliferation occur at sites other than or in addition to these early events in cellular activation. |
| Databáze: | OpenAIRE |
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