Microalbuminuria in Essential Hypertension

Autor: Badiger, Sharan, Prema T. Akkasaligar, HM, Sandeep, Biradar MS
Jazyk: angličtina
Rok vydání: 2011
Předmět:
DOI: 10.5281/zenodo.1084494
Popis: Essential hypertension (HTN) usually clusters with other cardiovascular risk factors such as age, overweight, diabetes, insulin resistance and dyslipidemia. The target organ damage (TOD) such as left ventricular hypertrophy, microalbuminuria (MA), acute coronary syndrome (ACS), stroke and cognitive dysfunction takes place early in course of hypertension. Though the prevalence of hypertension is high in India, the relationship between microalbuminuria and target organ damage in hypertension is not well studied. This study aim at detecting MA in essential hypertension and its relation to severity of HTN, duration of HTN, body mass index (BMI), age and TOD such as HTN retinopathy and acute coronary syndrome The present study was done in 100 patients of essential hypertension non diabetics admitted to B.L.D.E.University-s Sri B.M.Patil Medical College, Bijapur, from October 2008 to April 2011. The patients underwent detailed history and clinical examination. Early morning 5 ml of urine sample was collected & MA was estimated by immunoturbidometry method. The relationship of MA with the duration & severity of HTN, BMI, age, sex and TOD's like hypertensive retinopathy, ACS was assessed by univariate analysis. The prevalence of MA in this study was found to be 63 %. In that 42% were male & 21% were female. In this study a significant association between MA and the duration of hypertension (p = 0.036) & (OR =0.438). Longer the duration of hypertension, more possibility of microalbumin in urine. Also there was a significant association between severity of hypertension and MA (p=0.045) and (OR=0.093). MA was positive in 50 (79.4%) patients out of 63, whose blood pressure was >160/100 mm Hg. In this study a significant association between MA and the grades of hypertensive retinopathy (p =0.011) and acute coronary syndrome (p = 0.041) (OR =2.805). Gender and BMI did not pose high risk for MA in this study.The prevalence of MA in essential hypertension is high in this part of the community and MA will increase the risk of developing target organ damage.Early screening of patients with essential hypertension for MA and aggressive management of positive cases might reduce the burden of chronic kidney diseases and cardiovascular diseases in the community.
{"references":["Roberto Pedrinelli, Giuseppe Penno,Giulia Dell'Omo, Simona\nBandinelli, Davide Giorgi, Vitantonio Di Bello ,\" Microalbuminuria and\ntranscapillary albumin leakage in essential hypertension\", Hypertension.\n1999; 34, pp.491-495","Antonio Ceriello., \"Possible role of oxidative stress in the pathogenesis\nof hypertension\", 2008 ; 31,pp. S181-S1","Hithal.B, Pappachan.J.M, Balachandran Pillai.H, Sujathan. P,\nRamakrishna. C. D, \"Microalbuminuria in patients with essential\nhypertension and its relationship to target organ damage: An Indian\nExperience\", 2008; 19 (3), pp. 411.","Jan Skov Jensen, Bo Feldt- Rasmussen, Svend Strandgaard, Marianne\nSchroll, Knut Borch-Johnsen., \" Hypertension, microalbuminuria and\nrisk of ischaemic heart disease\", Hypertension 2000 ; 35 ,pp. 898-903.","Sainani.G.S, Vibhuti Maru.G.\" Role of endothelial cell dysfunction in\nessential hypertension\", .JAPI. 52; 2004, pp.966- 969.","Roberto Pontremoli, Antonella Sofia, Maura Ravera.\"Prevalence and\nclinical correlates of microalbuminuria in essential hypertension\".The\nMAGIC study .Hypertension. 1997; 30, pp. 1135-1143.","Diercks GFH, Von Boren AJ, Hillege HL, Janssen WMT, Kors JA,\nDeJong PE. \"Microalbuminuria is independently associated with\nischemic electrocardiographic abnormalities is a large non-diabetic\npopulation\", The PREVEND study. Eur Heart J. 2000 ; 21 , pp. 1922-\n1927","Jensen JS, Feldt-Rasmussen B, Strandgaard S, Schroll M, Borch-\nJohnson K. \" Arterial hypertension, microalbuminuria and risk of\nischemic heart disease\", Hypertension 2000 ; 35 , pp. 898-903","Bhaskar E, Shanta GPS, Kumar A,Sundaram V, \"Accuracy of retinal\nchanges in predicting microalbuminuria among elderly hypertensive\npatients: A cross-sectional study from a teaching hospital in South\nIndia.A cross sectional study from a teaching hospital in south India,\n2008\", Int Urol Nephrol,Nephrology original paper.\n[10] Jay Garg.P, George Bakris.L,\" Microalbuminuria: marker of vascular \ndysfunction, risk factor for cardiovascular disease\", Vasc Med. 2002; \npp.7-35."]}
Databáze: OpenAIRE
Externí odkaz: