Extreme short stature after intrauterine growth retardation: factors associated with lack of catch-up growth
| Autor: | Raja Brauner, T. Edouard, E. Lawson-Body, Jean-Claude Souberbielle, Christine Trivin, Graziella Pinto |
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| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Extreme short stature Endocrinology Diabetes and Metabolism medicine.medical_treatment Biology Growth hormone Short stature Insulin-like growth factor Endocrinology Child Development Pregnancy Internal medicine medicine Humans Psychology Insulin-Like Growth Factor I Child Growth Disorders Fetus Fetal Growth Retardation Growth retardation Growth factor Body Weight Infant Newborn Syndrome Body Height Growth hormone treatment Pediatrics Perinatology and Child Health Infant Small for Gestational Age Female medicine.symptom |
| Zdroj: | Hormone research. 61(1) |
| ISSN: | 0301-0163 |
| Popis: | The factors associated with lack of catch-up growth after intrauterine growth retardation (IUGR) are unknown. Objective: To identify these factors by analyzing the clinical features and growth hormone (GH)-insulin-like growth factor I (IGF-I) axis. Methods: 95 patients with height Results: They were seen at 5.3 ± 0.5 and 4 ± 0.5 year (p = 0.02) with heights at –3.4 ± 0.1 and –3.9 ± 0.2 SD (p = 0.03). Group 1 differed from group 2 in having a lower frequency of consanguinity (2 vs. 28.9%, p < 0.001), and higher frequencies of target heights (26.5 vs. 6.7%, p = 0.02) and mothers’ heights (34.7 vs. 8.9%, p < 0.01) Conclusion: The short height of the parents, particularly of the mother, is associated with factors limiting the catch-up growth after IUGR of children without malformations, while the high frequency of consanguinity in those with malformations suggests that transmitted fetal factors affect organogenesis or development. |
| Databáze: | OpenAIRE |
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