Lack of association of liver fat with model parameters of beta-cell function in men with impaired glucose tolerance and type 2 diabetes
| Autor: | Saskia Bontemps, Andrea Mari, Petra J. W. Pouwels, Maarten E Tushuizen, Michaela Diamant, Mathijs C. Bunck |
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| Přispěvatelé: | Gastroenterology and hepatology, Human genetics, Physics and medical technology, Internal medicine, Neuroscience Campus Amsterdam 2008, ICaR - Ischemia and repair |
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Type 2 diabetes Biology Models Biological Impaired glucose tolerance Endocrinology Insulin resistance Internal medicine Diabetes mellitus Insulin-Secreting Cells Glucose Intolerance medicine Humans Aged Insulin General Medicine Middle Aged Models Theoretical medicine.disease Obesity Adipose Tissue Diabetes Mellitus Type 2 Liver Case-Control Studies Steatosis Metabolic syndrome |
| Zdroj: | Tushuizen, M E, Bunck, M C M, Pouwels, P J W, Bontemps, S, Mari, A & Diamant, M 2008, ' Lack of association of liver fat with model parameters of beta-cell function in men with impaired glucose tolerance and type 2 diabetes ', European Journal of Endocrinology, vol. 159, no. 3, pp. 251-257 . https://doi.org/10.1530/EJE-08-0424 European Journal of Endocrinology, 159(3), 251-257. BioScientifica Ltd. |
| ISSN: | 0804-4643 |
| DOI: | 10.1530/EJE-08-0424 |
| Popis: | ObjectiveHepatic steatosis and obesity are components of the metabolic syndrome and risk factors for developing type 2 diabetes (T2DM). We studied how liver fat and body fat distribution relate to various aspects of β-cell function.MethodsIn 12 men with T2DM, 10 men with impaired glucose tolerance (IGT), and 14 age- and body mass index-matched controls, we measured body fat distribution and liver fat by magnetic resonance imaging and spectroscopy. An oral glucose tolerance test was performed to calculate insulin secretory rate (ISR) by C-peptide deconvolution, and β-cell function using a mathematical model that describes ISR as a function of absolute glucose levels (insulin secretory tone and glucose sensitivity), the glucose rate of change (rate sensitivity), and a potentiation factor.ResultsWaist circumference and the various body fat compartments did not differ among groups. IGT had the highest total and late phase insulin secretion (PP=0.006). In spite of the hypersecretion, IGT had β-cell glucose sensitivity, rate sensitivity, and potentiation similar to controls. Liver fat content was highest in diabetic patients (P=0.004) and showed the strongest association with total and late phase of insulin secretion in the IGT group (r=0.657, P=0.039 and r=0.732, P=0.016 respectively). Model β-cell function variables showed no association with liver fat or body fat compartments.ConclusionsThese data suggest that, in spite of the association of central adiposity and liver fat with T2DM risk, additional, hitherto unknown factors may contribute to β-cell dysfunction in susceptible humans. |
| Databáze: | OpenAIRE |
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