Association analysis of PDE4B polymorphisms with schizophrenia and smooth pursuit eye movement abnormality in a Korean population
| Autor: | Jason Yongha Kim, Tae Min Shin, Jae Won Kim, Chul-Soo Park, Cheol-Soon Lee, Hyoung Doo Shin, Jaeuk Hwang, Woo Hyuk Choi, Sung Il Woo, Hyun Sub Cheong, In Song Koh, Byung Lae Park, Suhg Namgoong, Bong Jo Kim, Jeong Hyun Kim, Ji On Kim, Joon Seol Bae |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Candidate gene Physiology Biophysics Single-nucleotide polymorphism Comorbidity Polymorphism Single Nucleotide Young Adult DISC1 Ocular Motility Disorders PDE4B Japan Risk Factors Prevalence Humans Medicine Genetic Predisposition to Disease Genetic Association Studies Genetic association Genetics Korea biology business.industry Haplotype General Medicine Middle Aged medicine.disease Cyclic Nucleotide Phosphodiesterases Type 4 Schizophrenia biology.protein Female Abnormality business |
| Zdroj: | General physiology and biophysics. 34:277-284 |
| ISSN: | 1338-4325 |
| DOI: | 10.4149/gpb_2015004 |
| Popis: | Schizophrenia is a debilitating mental disorder with a high heritability rate. Located on chromosome 1p31.3, the human cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B) gene has been considered as an important candidate gene for the risk of schizophrenia. Several genetic association studies reported the association between PDE4B polymorphisms and the risk of schizophrenia in Caucasian, African American, Indian, and Japanese populations. The aim of this study is to examine the association of PDE4B variations with schizophrenia and smooth pursuit eye movement (SPEM) abnormality in a Korean population. A case-control association analysis was carried out by comparing the genotype distribution of eight PDE4B polymorphisms between 457 schizophrenia patients and 386 normal healthy subjects. Differences in the frequency distribution of PDE4B single nucleotide polymorphisms (SNPs) and haplotypes were analyzed by logistic regression analyses controlling for age as a covariate. Statistical analyses revealed nominal significant associations of rs1040716, rs472952, rs1321177, and rs2144719 with the risk of schizophrenia (p = 0.02~0.05). The rs11208756 polymorphism showed a nominal significant association with SPEM abnormality (p = 0.05). In a meta-analysis with Japanese and Korean populations, three SNPs (rs472952, rs1040716, and rs2180335) revealed significant associations with schizophrenia (meta-p value = 0.0038~0.019). Our results support previously reported association of PDE4B variations with schizophrenia in other populations. The findings in this study add a new evidence for the involvement of PDE4B gene in schizophrenia etiology. |
| Databáze: | OpenAIRE |
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