Lipid profile and left ventricular geometry pattern in obese children
| Autor: | Maciej Banach, Sergej Prijic, Vladimir Vukovic, Claudia Stefanutti, Sanja Stankovic, Stevo Lukic, Aleksandra Klisic, Maja Jović, Bojko Bjelakovic, Nebojsa Kavaric, Marko Bjelakovic, Ljiljana Saranac |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry 030204 cardiovascular system & hematology Left ventricular hypertrophy Body Mass Index chemistry.chemical_compound 0302 clinical medicine Endocrinology High-density lipoprotein Insulin Child lcsh:RC620-627 Children children left ventricular mass index obesity relative wall thickness triglycerides medicine.diagnostic_test Lipids lcsh:Nutritional diseases. Deficiency diseases Cholesterol Echocardiography Cardiology Female Hypertrophy Left Ventricular Serbia medicine.medical_specialty Adolescent Heart Ventricles 030209 endocrinology & metabolism Clinical nutrition 03 medical and health sciences Internal medicine medicine Humans Obesity Risk factor Triglycerides Dyslipidemias business.industry Research Biochemistry (medical) Cholesterol HDL Relative wall thickness Cholesterol LDL medicine.disease Blood pressure Cross-Sectional Studies chemistry Lipid profile business Left ventricular mass index |
| Zdroj: | Lipids in Health and Disease Lipids in Health and Disease, Vol 19, Iss 1, Pp 1-7 (2020) |
| Popis: | Background Left ventricular hypertrophy (LVH) is an important risk factor for cardiovascular and all-cause mortality. Previous studies reported conflicting results concerning the relationship between serum lipid levels and left ventricular geometry pattern. We sought to explore the relationship between standard serum lipid profile measures with left ventricular geometry pattern in obese children. Patients and methods In this cross-sectional study, a total of 70 obese children were examined. Fasting blood samples were taken to measure total cholesterol, low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglycerides (TGs), glucose, and insulin. Based on these values TG/HDL ratio, BMI and HOMA index were calculated. We also measured the average 24-h ambulatory systolic blood pressure (SBP) and two-dimensional (2/D) transthoracic echocardiography was performed to determine left ventricular mass index (LVMI) and relative wall thickness (RWT). Multiple regression analyses were conducted to explore relationships between study variables and the LVMI or RWT as outcome variables. The final model with LVMI included TG/HDL ratio, BMI, 24 h-average SBP, age and sex, while for the RWT we included BMI, insulin, age and sex. Results Our study included 70 children (65.71% boys and 34.29% girls) median age (14 years, IQR = 12–16)." We demonstrated independent and positive association of TG/HDL ratio, BMI and 24 h-average SBP with LVMI (effect = 3.65, SE = 1.32, p p = 0.01 Insulin: effect = 2.80, SE = 0.97). Conclusion Increased TG/HDL ratio in obese children is associated with the development of eccentric left ventricular hypertrophy while increased BMI and insulin were associated with concentric left ventricular hypertophy. |
| Databáze: | OpenAIRE |
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