Clinical, pathological, immunohistochemical and molecular characterization of feline chronic gingivostomatitis
| Autor: | Saulo Petinatti Pavarini, Fernanda Viera Amorim da Costa, Paulo Michel Roehe, David Driemeier, Marcelo de Souza Muccillo, Fabrício Souza Campos, Víviam Nunes Pignone, Cláudia Stringhini Faraco, Veronica Machado Rolim |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Pathology medicine.medical_specialty Feline immunodeficiency virus 040301 veterinary sciences Immunodeficiency Virus Feline Cat Diseases Polymerase Chain Reaction Feline leukemia virus 0403 veterinary science 03 medical and health sciences Animals Medicine Small Animals Stomatitis Feline calicivirus CATS biology business.industry Leukemia Virus Feline 04 agricultural and veterinary sciences biology.organism_classification medicine.disease Gingivitis Immunohistochemistry Caliciviridae 030104 developmental biology Cats Female Histopathology business |
| Zdroj: | Journal of Feline Medicine and Surgery. 19:403-409 |
| ISSN: | 1532-2750 1098-612X |
| Popis: | Objectives This study presents the clinical, pathological, immunohistochemical and molecular characterization of 26 cats with feline chronic gingivostomatitis (FCG). Methods Oral mucosal biopsies, blood and swabs were collected from cats presenting with oral lesions. The tissue sections were submitted for histopathology and immunohistochemical analysis for feline calicivirus (FCV), feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV). The swabs were subjected to PCR analysis for FCV, and blood for FeLV and FIV. Results The main clinical findings were dysphagia (88.2%), halitosis (76.5%), sialorrhea (47.1%), weight loss (41.2%), intense oral discomfort (35.3%), oral hemorrhage (17.6%), and lackluster and fragile coat (11.8%). Gross inspection revealed bilateral lesions across the palatoglossal fold to the lateral tongue base. The lesions were diffuse, proliferative, intensely red and friable, and bled easily upon examination in 80.8% of cases. In 23.1% of cases, the lesions were multifocal to coalescent, at times forming multiple vesicles on a reddened, edematous palatoglossal fold. Microscopic examination showed that 15.4% of lesions had moderate (grade 2) and 84.6% had severe (grade 3) inflammation. Immunohistochemistry revealed the presence of FeLV antigens in the epithelium and the inflammatory infiltrate of 30.8% of the cats with FCG. FCV antigens were not detected in the FCG lesions. Conclusions and relevance The FCG cases analyzed could not be correlated with FCV. It is possible that FeLV plays a role as a causal agent of lesions in cases where the presence of the virus has been confirmed by immunohistochemistry in epithelial samples. |
| Databáze: | OpenAIRE |
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