GC rich DNA oligonucleotides with narrow minor groove width
| Autor: | Kimiko Umemoto, Ramaswamy H. Sarma, Linsen Dai, Mukti H. Sarma |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Guanine
Stereochemistry Biophysics Biochemistry Pyrimidine-purine junction 2D NOESY in water Cytosine Local sequence chemistry.chemical_compound Structural Biology Adenine nucleotide Genetics GC rich DNA oligomer 2D NMR Nuclear Magnetic Resonance Biomolecular Molecular Biology Groove (engineering) Minor groove width Base Composition Base Sequence Chemistry Oligonucleotide DNA Cell Biology Nuclear magnetic resonance spectroscopy Oligodeoxyribonucleotides Nucleic Acid Conformation Purine-pyrimidine junction Two-dimensional nuclear magnetic resonance spectroscopy Minor groove |
| Zdroj: | FEBS Letters. 418:76-82 |
| ISSN: | 0014-5793 |
| DOI: | 10.1016/s0014-5793(97)01351-3 |
| Popis: | Investigation of the width of the minor groove using 500 MHz NMR spectroscopy in three closely related 11-mer B-DNA duplexes shows that the minor groove is narrow in a GC rich oligonucleotide, and that a narrow minor groove is not something endemic to DNAs with persistent repetitions of adenine nucleotides (A-tract DNA). The width of the groove is dictated by local sequence contexts and independent of neighboring A-tract DNA. |
| Databáze: | OpenAIRE |
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