Infection Complications and Pattern of Bacterial Resistance in Living-Donor Liver Transplantation: A Multicenter Epidemiologic Study in Egypt
| Autor: | A. Mukhtar, A. Abdelaal, M. Hussein, H. Dabous, I. Fawzy, G. Obayah, A. Hasanin, N. Adel, D. Ghaith, M. Bahaa, M. Fathy, M. El Meteini |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Drug resistance Liver transplantation Antibiotic resistance Risk Factors Internal medicine Drug Resistance Bacterial Living Donors medicine Humans Risk factor Intensive care medicine Transplantation business.industry Incidence Incidence (epidemiology) Medical record Bacterial Infections Middle Aged Liver Transplantation Multicenter study Egypt Female Surgery business |
| Zdroj: | Transplantation Proceedings. 46:1444-1447 |
| ISSN: | 0041-1345 |
| DOI: | 10.1016/j.transproceed.2014.02.022 |
| Popis: | Data on the prevalence and pattern of infection after living-donor liver transplantation (LDLT) are scarce in Egypt. We therefore conducted this study to quantify the incidence, risk factors, and pattern of bacterial resistance post-LDLT in 3 hospitals in Egypt.We conducted a retrospective, multicenter study of the medical records of 246 patients who underwent LDLT between January 2006 and April 2011 at 3 transplant centers in Egypt.Of 246 patients enrolled in this study, 127 (52%) developed infectious complications after LDLT, with 416 episodes of infection occurring within 3 months of transplantation. Biliary tract infection was the most common, occurring in 169 (40.6%) patients. The rate of infection with Gram-negative bacteria was higher than that of infection with Gram-positive bacteria (310 [74%] vs 87 [21%]; P.001). Overall, 75% of Gram-negative isolates were multidrug resistant. Significant independent risk factors for infection were portal vein thrombosis (odds ratio, 2.4; P = .037) and biliary complications (odds ratio, 5.4; P.001).Our data showed a high-resistance pattern of bacterial infection after LDLT in Egypt. Early biliary complications were an independent risk factor for bacterial infection. |
| Databáze: | OpenAIRE |
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