In vivo measurement of Pu dissolution parameters of MOX aerosols and related uncertainties in the values of the dose per unit intake
| Autor: | B. Ramounet-Le Gall, G. Rateau, J. Delforge, M.-C. Abram, Eric Ansoborlo, G. Grillon, P. Bérard, P. Fritsch |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
Metabolic Clearance Rate Analytical chemistry Radiation Dosage Models Biological Sensitivity and Specificity Standard deviation Absorption Rats Sprague-Dawley In vivo Animals Computer Simulation Radiology Nuclear Medicine and imaging Radiometry Lung Dissolution MOX fuel Aerosols Inhalation exposure Inhalation Exposure Radiation Radiological and Ultrasound Technology Chemistry business.industry Public Health Environmental and Occupational Health Reproducibility of Results Oxides General Medicine Plutonium Rats Air Pollutants Radioactive Radioactive Waste Nuclear medicine business |
| Zdroj: | ResearcherID |
| ISSN: | 1742-3406 0144-8420 |
| DOI: | 10.1093/oxfordjournals.rpd.a006212 |
| Popis: | The aim of this study was to compare dissolution parameter values for Pu from industrial MOX with different Pu contents. For this purpose, preliminary results obtained after inhalation exposure of rats to MOX containing 2.5% Pu are reported and compared to those obtained previously with MOX containing 5% Pu. Dissolution parameter values appear to increase when the amount of Pu decreases. Rapid fractions, f(r), of 4 x 10(-3) (s.d. = 2 x 10(-3)) and 1 x 10(-3) (s.d. = 6 x 10(-4)) and slow dissolution rates, s(s) of 2 x 10(-4) d(-1) (standard deviation, sigma = 5 x 10(-5)) and 5 x 10(-5) d(-1) (sigma = 1 x 10(-5)) were derived for MOX containing 2.5 and 5% of Pu, respectively. Simulations were performed to assess uncertainties on dose due to experimental errors. The relative standard deviations of the dose per unit intake (DPUI) due to f(r) (4-8%), are far less than those due to s(s) (about 20%), which is the main parameter altering the dose. Although quite different dissolution parameter values were derived, similar DPUIs were obtained for MOX aerosols containing 2.5 and 5% Pu which appear close to that for default Type S values. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|