Association between Cardiovascular Risk and Diabetes with Colorectal Neoplasia: A Site-Specific Analysis
| Autor: | Christian Schmied, Christian Datz, Ursula Huber-Schönauer, Elmar Aigner, Isabelle Bracher, Felix Stickel, Dieter Lederer, Sabrina Hammerl, Wolfgang Patsch, Martin Plöderl, Slayman Obeid, Andreas Stadlmayr, David Niederseer |
|---|---|
| Přispěvatelé: | University of Zurich |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
cardiovascular risk
medicine.medical_specialty Heart Score (HS) Colorectal cancer Rectum Colonoscopy lcsh:Medicine 610 Medicine & health Type 2 diabetes Colorectal adenoma 030204 cardiovascular system & hematology Gastroenterology Asymptomatic Article 03 medical and health sciences 0302 clinical medicine site-specific colorectal neoplasia Internal medicine medicine Framingham Risk Score medicine.diagnostic_test business.industry lcsh:R Framingham Risk Score (FRS) General Medicine medicine.disease digestive system diseases 10219 Clinic for Gastroenterology and Hepatology medicine.anatomical_structure Cohort 10209 Clinic for Cardiology 030211 gastroenterology & hepatology medicine.symptom business |
| Zdroj: | Journal of Clinical Medicine Journal of Clinical Medicine, Vol 7, Iss 12, p 484 (2018) Volume 7 Issue 12 |
| ISSN: | 2077-0383 |
| Popis: | Several studies have shown site-specific differences in colorectal cancer (CRC) with respect to the risk factors. CRC was shown to be associated with cardiovascular risk (CVR) factors, but site-specific variations have not been investigated so far. This study aimed to assess the associations between the prevalence and subsite-specific differences of colorectal neoplasia and established CVR scores or known coronary artery disease (CAD) in a large asymptomatic European screening cohort (N = 2098). Participants underwent simultaneous screening colonoscopy and CVR evaluation, using the Framingham Risk Score and Heart Score. Lesions found in the colonoscopy were classified by location (proximal/distal colon or rectum). More neoplasias were found in the proximal versus the distal colon (p < 0.001). The Framingham Risk Score and Heart Score showed incremental risk for colorectal adenoma, across the tertiles in the proximal and the distal colon (p < 0.001). The prevalence of adenomas in the rectum was much lower, but also here, incremental risk could be shown for the Framingham Risk but not the Heart Risk Score tertiles. Prevalence of adenomas in the proximal colon was higher in subjects with type 2 diabetes (T2DM) (p = 0.006), but no association was found between adenomas and T2DM in the distal colon (p = 0.618) and the rectum (p = 0.071). Males had a higher CVR and more findings, in the screening colonoscopy, as compared to females, however, no site-specific differences were noted. Patients with known CAD and high CVR have an increased risk of colorectal neoplasia in both the proximal and distal colon. Patients with T2DM have a higher risk for neoplasia in the proximal colon. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |