Differential effect of an anticholinergic antidepressant on sleep-dependent memory consolidation
| Autor: | Monique Goerke, Stefan Cohrs, Andrea Rodenbeck, Dieter Kunz |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Polysomnography Amitriptyline Sleep REM pharmacology [Adrenergic Uptake Inhibitors] Anticholinergic agents Audiology Antidepressive Agents Tricyclic Procedural memory Cholinergic Antagonists Young Adult drug effects [Memory] Double-Blind Method Memory Physiology (medical) Task Performance and Analysis medicine Humans ddc:610 Declarative learning physiology [Memory] pharmacology [Cholinergic Antagonists] Effect of an Anticholinergic Antidepressant on Sleep-Dependent Memory medicine.diagnostic_test Adrenergic Uptake Inhibitors drug effects [Motor Skills] drug effects [Sleep] physiology [Sleep] drug effects [Sleep REM] Motor Skills Anesthesia pharmacology [Antidepressive Agents Tricyclic] physiology [Sleep REM] Antidepressant Memory consolidation Neurology (clinical) Sleep Reuptake inhibitor Psychology pharmacology [Amitriptyline] physiology [Motor Skills] medicine.drug |
| Zdroj: | Sleep 37(5), 977-985 (2014). doi:10.5665/sleep.3674 |
| DOI: | 10.5665/sleep.3674 |
| Popis: | STUDY OBJECTIVES Rapid eye movement (REM) sleep is considered critical to the consolidation of procedural memory - the memory of skills and habits. Many antidepressants strongly suppress REM sleep, however, and procedural memory consolidation has been shown to be impaired in depressed patients on antidepressant therapy. As a result, it is important to determine whether antidepressive therapy can lead to amnestic impairment. We thus investigated the effects of the anticholinergic antidepressant amitriptyline on sleep-dependent memory consolidation. DESIGN Double-blind, placebo-controlled, randomized, parallel-group study. SETTING Sleep laboratory. PARTICIPANTS Twenty-five healthy men (mean age: 26.8 ± 5.6 y). INTERVENTIONS 75 mg amitriptyline versus placebo. MEASUREMENTS/RESULTS To test memory consolidation, a visual discrimination task, a finger-tapping task, the Rey-Osterrieth Complex Figure Test, and the Rey Auditory-Verbal Learning Test were performed. Sleep was measured using polysomnography. Our findings show that amitriptyline profoundly suppressed REM sleep and impaired perceptual skill learning, but not motor skill or declarative learning. CONCLUSIONS Our study is the first to demonstrate that an antidepressant can affect procedural memory consolidation in healthy subjects. Moreover, considering the results of a recent study, in which selective serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors were shown not to impair procedural memory consolidation, our findings suggest that procedural memory consolidation is not facilitated by the characteristics of REM sleep captured by visual sleep scoring, but rather by the high cholinergic tone associated with REM sleep. Our study contributes to the understanding of potentially undesirable behavioral effects of amitriptyline. |
| Databáze: | OpenAIRE |
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