Polymorph evolution during crystal growth studied by 3D electron diffraction
| Autor: | Hongyi Xu, Xiaodong Zou, Simon Parsons, Edward T. Broadhurst, Fabio Nudelman, Max T. B. Clabbers, Molly Lightowler |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Continuous rotation
Materials science crystallization Kinetics Crystal growth 010402 general chemistry 01 natural sciences Biochemistry cryotem polymorphism law.invention 3ded law General Materials Science Crystallization Crystallography Aqueous solution 010405 organic chemistry General Chemistry Condensed Matter Physics Research Letters 0104 chemical sciences Electron diffraction Polymorphism (materials science) QD901-999 electron diffraction Crystallite glycine |
| Zdroj: | IUCrJ, Vol 7, Iss 1, Pp 5-9 (2020) Broadhurst, E T, Xu, H, Clabbers, M T B, Lightowler, M, Nudelman, F, Zou, X & Parsons, S 2020, ' Polymorph evolution during crystal growth studied by 3D electron diffraction ', IUCrJ, vol. 7, no. 1, pp. 5-9 . https://doi.org/10.1107/S2052252519016105 IUCrJ |
| ISSN: | 2052-2525 |
| DOI: | 10.1107/s2052252519016105 |
| Popis: | 3D electron diffraction has been used to follow polymorph evolution during the crystallization of glycine from pure water. All three known polymorphs formed sequentially in samples taken from the same solution and allowed to crystallize in situ at times between 3 and 60 min. Crystal structures were obtained for all three phases. 3D electron diffraction (3DED) has been used to follow polymorph evolution in the crystallization of glycine from aqueous solution. The three polymorphs of glycine which exist under ambient conditions follow the stability order β < α < γ. The least stable β polymorph forms within the first 3 min, but this begins to yield the α-form after only 1 min more. Both structures could be determined from continuous rotation electron diffraction data collected in less than 20 s on crystals of thickness ∼100 nm. Even though the γ-form is thermodynamically the most stable polymorph, kinetics favour the α-form, which dominates after prolonged standing. In the same sample, some β and one crystallite of the γ polymorph were also observed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|