CT characteristics and diagnostic value of COVID-19 in pregnancy
| Autor: | Lu Song, Wei Jin, Xiaochun Zhang, Hongjun Li, Xiao Ming Gong, Zhi Yan Lu, Heng Ning Ke, Kai Hu Yu, Li Li, Hang Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Pulmonology
Pleural effusion Physiology Maternal Health Fevers COVID-19 Nucleic acids Pregnancy Computed axial tomography Pneumonia Coughing Lesions Pathology and Laboratory Medicine Biochemistry Ground-glass opacity 030218 nuclear medicine & medical imaging Diagnostic Radiology 0302 clinical medicine Nucleic Acids Medicine and Health Sciences Medicine Pregnancy Complications Infectious Tomography 030219 obstetrics & reproductive medicine Multidisciplinary biology Reverse Transcriptase Polymerase Chain Reaction Radiology and Imaging Obstetrics and Gynecology medicine.anatomical_structure C-Reactive Protein Disease Progression Female medicine.symptom Coronavirus Infections Research Article Adult Imaging Techniques Science Pneumonia Viral Neuroimaging Research and Analysis Methods Lesion Fibrin Fibrinogen Degradation Products 03 medical and health sciences Betacoronavirus Signs and Symptoms Diagnostic Medicine White blood cell Humans Pandemics Retrospective Studies business.industry SARS-CoV-2 C-reactive protein Biology and Life Sciences Retrospective cohort study medicine.disease Computed Axial Tomography Pleural Effusion biology.protein Women's Health Nuclear medicine business Physiological Processes Tomography X-Ray Computed Neuroscience Follow-Up Studies |
| Zdroj: | PLOS ONE, 15(7):e0235134 PLoS ONE PLoS ONE, Vol 15, Iss 7, p e0235134 (2020) |
| Popis: | ObjectiveTo investigate the computed tomography (CT) characteristics and diagnostic value of novel coronavirus pneumonia (NCP or COVID-19) in pregnancy.MethodsThis study included ten pregnant women infected with COVID-19, treated in the Zhongnan Hospital of Wuhan University from January 20, 2020 to February 6, 2020. Clinical and chest CT data were collected and clinical symptoms, laboratory indicators, and CT images were analyzed to explore CT characteristics and diagnostic value for COVID-19 during pregnancy.ResultsLaboratory examination showed that white blood cell count was normal in nine patients, and slightly higher in one patient (10.23 × 109). The lymphocyte ratio decreased in two patients by 12% and 14%, respectively. The levels of C-reactive protein was elevated in seven patients (range, 21.16-60.3 mg/L) and the levels of D-dimer was increased in eight patients (range, 507-2141 ng/mL). Six patients had low levels of total protein (range, 35.3-56.5 mg/L). Two patients showed small patchy ground glass opacity (GGO) involving single lung, while eight patients showed multilobe GGO in both the lungs, with partial consolidation. Peripheral and non-peripheral lesion distributions were seen in ten (100%) and four (40%) patients, respectively. There were four patients who had signs of intra-bronchial air-bronchogram, six patients had small bilateral pleural effusions, while none had lymphadenopathy. Dynamic observations were performed in four patients after COVID-19 treatment. Among these four patients, one patient showed normal on the initial examination, and new lesions were observed after 3 days; 1 patient showed progression after 7 days of treatment, with expansion of the lesion area; and the other 2 patients showed improvement after 14 days of treatment, with reduction in the density and area of lesions and appearance of linear opacity.ConclusionsThe CT characteristics of COVID-19 in pregnancy were mainly observed in early and progressive stages, and multiple new lesions were common. And there were consolidations of varying sizes and degrees within the lesion. Moreover, the original ground glass lesions could be fused or partially absorbed. Six patients had small bilateral pleural effusion. In summary, CT scans can play an important role in early screening, dynamic observation, and efficacy evaluation of suspected or confirmed cases of pregnant women with COVID-19. |
| Databáze: | OpenAIRE |
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