Down's syndrome: morphological remodelling and increased complexity in the neuromuscular junction of transgenic CuZn-superoxide dismutase mice
| Autor: | S. Rotshenker, Karen B. Avraham, Yoram Groner, H. Sugarman |
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| Rok vydání: | 1991 |
| Předmět: |
Male
Genetically modified mouse Aging medicine.medical_specialty Histology Transgene Neuromuscular Junction Gene Expression Mice Transgenic Hindlimb Biology Muscle Development Gene dosage Neuromuscular junction Synapse Superoxide dismutase Mice Dosage Compensation Genetic Internal medicine medicine Animals Humans Superoxide Dismutase Muscles General Neuroscience Cell Biology Anatomy medicine.anatomical_structure Endocrinology biology.protein Female Dismutase Down Syndrome |
| Zdroj: | Journal of Neurocytology. 20:208-215 |
| ISSN: | 1573-7381 0300-4864 |
| Popis: | Transgenic mice carrying the human CuZn-superoxide dismutase gene were used to investigate whether CuZn-superoxide dismutase gene dosage is involved in the signs of neuromuscular junction deterioration associated with Down's syndrome. Three parameters of neuromuscular junction morphology were studied in hindlimb muscles of CuZn-superoxide dismutase-transgenic mice and their non-transgenic littermates: nerve terminal length, number of nerve terminal branching points and incidence of sprouting that results in synapse formation. These parameters increased with advanced age and the increase occurred earlier in CuZn-superoxide dismutase-transgenic mice. Therefore, the data is in line with the possibility that CuZn-superoxide dismutase-transgenic mice are undergoing premature ageing with respect to neuromuscular junction morphology, most probably owing to a gene dosage effect of CuZn-superoxide dismutase. |
| Databáze: | OpenAIRE |
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