Aberrant Lipid Metabolism in Hepatocellular Carcinoma Revealed by Liver Lipidomics
| Autor: | Yangyang Zhang, Jiye Zhu, Yu Lin, Ming Guan, Zhao Li, Xiao Cui, Zhenwen Zhao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
triacylglycerols phosphatidylcholine ceramide mass spectrometry UPLC-ESI-QTOF MS Ceramide Carcinoma Hepatocellular Ceramides Catalysis Article Mass Spectrometry Inorganic Chemistry lcsh:Chemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Lipidomics medicine Physical and Theoretical Chemistry Molecular Biology lcsh:QH301-705.5 Spectroscopy Triglycerides chemistry.chemical_classification Organic Chemistry Liver Neoplasms Lipid metabolism General Medicine medicine.disease Lipid Metabolism digestive system diseases Computer Science Applications 030104 developmental biology chemistry Biochemistry lcsh:Biology (General) lcsh:QD1-999 030220 oncology & carcinogenesis Hepatocellular carcinoma Spectrometry Mass Matrix-Assisted Laser Desorption-Ionization Cancer research Steatohepatitis Sphingomyelin Liver cancer Polyunsaturated fatty acid |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences; Volume 18; Issue 12; Pages: 2550 International Journal of Molecular Sciences, Vol 18, Iss 12, p 2550 (2017) |
| ISSN: | 1422-0067 |
| Popis: | Background: The aim of this study was to characterize the disorder of lipid metabolism in hepatocellular carcinoma (HCC). HCC is a worldwide disease. The research into the disorder of lipid metabolism in HCC is very limited. Study of lipid metabolism in liver cancer tissue may have the potential to provide new insight into HCC mechanisms. Methods: A lipidomics study of HCC based on Ultra high performance liquid chromatography-electronic spray ionization-QTOF mass spectrometer (UPLC-ESI-QTOF MS) and Matrix assisted laser desorption ionization-fourier transform ion cyclotron resonance mass spectrometer (MALDI-FTICR MS) was performed. Results: Triacylglycerols (TAGs) with the number of double bond (DB) > 2 (except 56:5 and 56:4 TAG) were significantly down-regulated; conversely, others (except 52:2 TAG) were greatly up-regulated in HCC tissues. Moreover, the more serious the disease was, the higher the saturated TAG concentration and the lower the polyunsaturated TAG concentration were in HCC tissues. The phosphatidylcholine (PC), phosphatidylethanolamine (PE) and phosphatidylinositol (PI) were altered in a certain way. Sphingomyelin (SM) was up-regulated and ceramide (Cer) were down-regulated in HCC tissues. Conclusions: To our knowledge, this is the first such report showing a unique trend of TAG, PC, PE and PI. The use of polyunsaturated fatty acids, like eicosapentanoic and docosahexanoic acid, as supplementation, proposed for the treatment of Non-alcoholic steatohepatitis (NASH), may also be effective for the treatment of HCC. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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