In vitro studies of deferasirox derivatives as potential organelle-targeting traceable anti-cancer therapeutics

Autor:	Dan-Ying Huang, Hai-Hao Han, Axel Steinbrueck, Xiao-Peng He, Adam C. Sedgwick, Michael Y. Zhao, Sajal Sen, Jia Li, Yi Zang, Jonathan L. Sessler
Rok vydání:	2021
Předmět:	Article Catalysis 03 medical and health sciences 0302 clinical medicine Fluorescent cell Lysosome Organelle Materials Chemistry medicine Lung cancer 030304 developmental biology 0303 health sciences Chemistry Deferasirox Metals and Alloys Cancer General Chemistry medicine.disease In vitro Surfaces Coatings and Films Electronic Optical and Magnetic Materials medicine.anatomical_structure 030220 oncology & carcinogenesis Ceramics and Composites Cancer research medicine.drug
Zdroj:	Chem Commun (Camb)
ISSN:	1364-548X 1359-7345
Popis:	We report here strategic functionalization of the FDA approved chelator deferasirox (1) in an effort to produce organelle-targeting iron chelators with enhanced activity against A549 lung cancer cells. Derivative 8 was found to have improved antiproliferative activity relative to 1. Fluorescent cell imaging revealed that compound 8 preferentially localises within the lysosome.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0df7c9b600b88aab7080d3090deb97cf https://doi.org/10.1039/d0cc08156f Zobrazit plný text záznamu