The effect of triclosan coated sutures on rate of surgical site infection after hip and knee replacement: a protocol for a double-blind randomised controlled trial
| Autor: | S. D. Muller, Mike R. Reed, Roland Pratt, Nicholas R. Parsons, Cyrus D. Jensen, Seif Asaad, Ian Carluke, Andrew P. Sprowson, Kevin P Emmerson, P Partington |
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| Rok vydání: | 2013 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty Time Factors Sports medicine medicine.medical_treatment Arthroplasty Replacement Hip Knee replacement Knee Joint law.invention Study Protocol Rheumatology Randomized controlled trial Clinical Protocols Coated Materials Biocompatible Double-Blind Method law Epidemiology medicine Humans Surgical Wound Infection Orthopedics and Sports Medicine Arthroplasty Replacement Knee Sutures business.industry Suture Techniques Health Care Costs Length of Stay Arthroplasty Triclosan Surgery Regimen Treatment Outcome England Research Design Orthopedic surgery Physical therapy Anti-Infective Agents Local business RD |
| Zdroj: | BMC Musculoskeletal Disorders |
| ISSN: | 1471-2474 |
| Popis: | 187,000 hip and knee joint replacements are performed every year in the National Health Service (NHS). One of the commonest complications is surgical site infection (SSI), and this represents a significant burden in terms of patient morbidity, mortality and cost to health services around the world. The aim of this randomised controlled trial (RCT) is to determine if the addition of triclosan coated sutures to a standard regimen can reduce the rate of SSI after total knee replacement (TKR) and total hip replacement (THR). 2400 patients due to undergo a total hip or knee replacement are being recruited into this two-centre RCT. Participants are recruited before surgery and randomised to either standard care or intervention group. Participants, outcome assessors and statistician are blind to treatment allocation throughout the study. The intervention consists of triclosan coated sutures vs. standard non-coated sutures. The primary outcome is the Health protection Agency (HPA) defined superficial surgical site infection at 30 days. Secondary outcomes include HPA defined deep surgical site infection at 12 months, length of hospital stay, critical care stay, and payer costs. To date there are no orthopaedic randomised controlled trials on this scale assessing the effectiveness of a surgical intervention, particularly those that can be translated across the surgical specialities. The results from this trial will inform evidence-based recommendations for suture selection in the management of patients undergoing total hip or knee replacement. If triclosan coated sutures are found to be an effective intervention, implementation into clinical practice could improve long-term outcomes for patients undergoing hip and knee replacement. Current Controlled Trials ISRCTN 17807356 . |
| Databáze: | OpenAIRE |
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