Effects of temporarily disrupting BBB on activity-induced manganese-dependent functional MRI
| Autor: | Yanjun Zeng, Zhibo Wen, Dingguo Gao, Qu Wu, Haigang Chang, Zhiqiang Fa, Jing Zhang, Yanping Liu, Run Zhang, Peng Li, Shaofang Zhu, Peng Zhang, Lujun Yang, Xiaodan Jiang, Fanheng Huang |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Visual perception genetic structures Cognitive Neuroscience chemistry.chemical_element Stimulation Manganese Stimulus (physiology) Behavioral Neuroscience Cellular and Molecular Neuroscience medicine Image Processing Computer-Assisted Animals Radiology Nuclear Medicine and imaging Mannitol Rats Wistar Diuretics Visual Cortex Image Enhancement Magnetic Resonance Imaging Rats Psychiatry and Mental health Visual cortex medicine.anatomical_structure nervous system Neurology chemistry Blood-Brain Barrier Data Interpretation Statistical cardiovascular system Neurology (clinical) Signal intensity Visual Fields Neuroscience Photic Stimulation |
| Zdroj: | Brain imaging and behavior. 5(3) |
| ISSN: | 1931-7565 |
| Popis: | This study further investigates the influence of temporarily disrupting the blood-brain barrier (BBB) on the level of manganese used in AIM fMRI other than the recognized function of allowing that substance to enter into the activated brain regions more effectively during the BBB opening. We injected manganese into Wistar rats through ICA following the disruption of BBB with mannitol in a functional MRI test of the visual cortex. Through comparing MRI signal intensity and manganese contents in the visual cortex of rats received visual stimuli of unequal degree after the restoration of BBB, we found that the signal in the visual cortex could be further enhanced on T1WI given visual stimulation after the restoration of BBB. Temporary BBB disruption has an additional advantage in allowing Mn(2+) to enter the CSF or brain for later transference to the activated brain area. So the dosage of manganese in AIM fMRI could be minimized by extending the stimulus. |
| Databáze: | OpenAIRE |
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