Rationalising the design of polymeric thermoresponsive biomaterials
| Autor: | T. A. Gorelova, Vincent P. Gilcreest, Yu. A. Rochev, B. K. Gavrilyuk, D. O'Halloran, I. S. Selezneva, Alexander V. Gorelov |
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| Rok vydání: | 2004 |
| Předmět: |
Materials science
Hot Temperature Polymers Surface Properties Statistics as Topic Biomedical Engineering Biophysics Cell Culture Techniques Bioengineering Biocompatible Materials Lower critical solution temperature Cell Line Biomaterials Mice Species Specificity Cell Line Tumor Polymer chemistry Materials Testing Copolymer Cell Adhesion Animals Humans Solubility Cell adhesion Laryngeal Neoplasms chemistry.chemical_classification Acrylamides Substrate (chemistry) Polymer Equipment Design Fibroblasts Surface energy Solvent chemistry Chemical engineering Cell Division |
| Zdroj: | Journal of materials science. Materials in medicine. 15(4) |
| ISSN: | 0957-4530 |
| Popis: | We investigated the cell adhesion and growth of a series of thermoresponsive copolymers of N-isopropylacrylamide (NIPA) and N-tert-butylacrylamide (NtBA) above their lower critical solubility temperatures (LCST). It was found that cell adhesion and growth on the solvent cast films improved with increasing the NtBA content in the copolymers. The improvement was dependent on cell line. The surfaces of copolymers were analysed by atomic force microscopy. The topography of polymer films was not dependent on composition. The differences in the cell attachment and growth were attributed to the variation of surface energy with composition. The surface energy of copolymers decreased with the increase in the NtBA content. We conclude that poly(N-isopropylacrylamide) (poly(NIPA)) is a relatively poor substrate for cell growth and proliferation. However, its ability to support cell growth can be significantly improved by suitable modification. |
| Databáze: | OpenAIRE |
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