Polyriboinosinic-Polyribocytidylic Acid-Poly-L-lysine Complex [Poly(ICL)] without Carboxymethylcellulose (CMC): A New Primate-Effective Interferon Inducer
| Autor: | Edward E. Stephens, Hilton B. Levy, Martin L. Morin, Eduard Lvovsky, Freddie L. Riley |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Male
musculoskeletal diseases Interferon Inducers Stereochemistry Lysine Polyriboinosinic-Polyribocytidylic Acid Mice Inbred Strains Vesicular stomatitis Indiana virus General Biochemistry Genetics and Molecular Biology Cell Line Mice Hydrolysis L Cells Interferon medicine Animals Humans Polylysine Inducer Skin Interferon inducer Chemistry technology industry and agriculture Macaca mulatta Macaca fascicularis Poly I-C Biochemistry Carboxymethylcellulose Sodium Biological Assay Female Interferons Peptides medicine.drug |
| Zdroj: | Experimental Biology and Medicine. 169:183-188 |
| ISSN: | 1535-3699 1535-3702 |
| Popis: | The complex of polyriboinosinic-polyribocytidylic (poly(I)·poly(C)) with poly-L-lysine in 0.5% carboxymethylcellulose (CMC) [poly(ICLC)] has proven to be an effective interferon inducer in primates, including man. Since no mechanism is known by which the body can degrade CMC, a new complex of lower molecular weight, which contains poly I·poly C complexed with poly-L-lysine [poly(ICL)] but without CMC, was developed. This compound is slightly more resistant than poly(ICLC) to hydrolysis by RNase-A and is also an effective inducer of interferon in nonhuman primates. The new compound without CMC is also less toxic in mice than is poly(ICLC) as indicated by LD50. |
| Databáze: | OpenAIRE |
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