Cipura paludosa attenuates long-term behavioral deficits in rats exposed to methylmercury during early development
| Autor: | Valdir Cechinel-Filho, Vania Moraes Ferreira, Rui Daniel Prediger, Élida G. Campos, Fábio A. Porto, Mariangela S. Azevedo, Greice M. R. S. Lucena |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Cerebellum Organogenesis Health Toxicology and Mutagenesis Motor Activity Hippocampal formation medicine.disease_cause Plant Roots Iridaceae chemistry.chemical_compound Pregnancy Internal medicine medicine Animals Hippocampus (mythology) Rats Wistar Maze Learning Methylmercury Swimming chemistry.chemical_classification Glutathione Peroxidase Behavior Animal biology Plant Extracts Glutathione peroxidase Public Health Environmental and Occupational Health General Medicine Anatomy Methylmercury Compounds Catalase Pollution Rats Cortex (botany) Oxidative Stress Endocrinology medicine.anatomical_structure chemistry Maternal Exposure Prenatal Exposure Delayed Effects biology.protein Female Water Pollutants Chemical Oxidative stress |
| Zdroj: | Ecotoxicology and Environmental Safety. 73:1150-1158 |
| ISSN: | 0147-6513 |
| Popis: | In the present study, we evaluated the effects of the ethanolic extract (EE) of Cipura paludosa on locomotor, and anxiety- and depression-like behaviors of adult rats exposed to MeHg during early development. Additionally, the antioxidant enzymes catalase (CAT) and selenium-glutathione peroxidase (Se-GPx) were measured in cortical, hippocampal, and cerebellar tissues. Pregnant Wistar rats were treated by gavage with a single dose of MeHg (8 mg/kg) on gestational day 15, the developmental stage critical for cortical neuron proliferation. Moreover, prenatal MeHg exposure inhibited CAT and Se-GPx in the cortex and cerebellum. Chronic treatment with the EE of C. paludosa attenuated these emotional and antioxidant deficits induced by prenatal MeHg toxic exposure. This study provides novel evidence that developmental exposure to MeHg can affect not only cognitive functions but also locomotor, and anxiety- and depression-like behaviors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect