Use of antiepileptic drugs in nontraumatic neurosurgical procedures. Is there any best route and time of administration?
| Autor: | Alberto Lazarowski, Ramon C. Leiguarda, Federico Demonty, Adrian Rabinowicz, Jorge Salvat, Fernando Salvat, Facundo Manes, Andrés Cervio |
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| Rok vydání: | 1997 |
| Předmět: |
Phenytoin
Adult Carotid Artery Diseases Male medicine.medical_treatment Administration Oral Neurosurgical Procedures Arteriovenous Malformations Route of administration Cerebrospinal fluid Pharmacokinetics Oral administration Seizures medicine Distribution (pharmacology) Humans Pharmacology (medical) Infusions Intravenous Aged Pharmacology Chemotherapy business.industry Brain Neoplasms Drug Administration Routes Middle Aged Aneurysm Anticonvulsant Anesthesia Anticonvulsants Female Neurology (clinical) business medicine.drug |
| Zdroj: | Clinical neuropharmacology. 20(5) |
| ISSN: | 0362-5664 |
| Popis: | We assessed in 15 consecutive patients the best route and time of administration for phenytoin (PHT) prophylaxis in neurosurgical procedures. We also correlated PHT levels in serum and cerebrospinal fluid after oral and parenteral loading doses. The mean PHT level was 13.9 micrograms/ml in serum and 2.03 micrograms/ml in cerebrospinal fluid (CSF), with a significant correlation between levels in both compartments (r = 0.73, p < 0.01). Mean PHT levels among the different groups were not statistically significant. We conclude that therapeutic levels of PHT in CSF can be achieved independently of the route of administration, as long as accepted loading doses are used. |
| Databáze: | OpenAIRE |
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