Comparison of Lansoprazole and Famotidine for Gastric Ulcer by Endoscopic Ultrasonography
| Autor: | Yildiran Songür, Yoshiharu Motoo, Takashi Okai, Hiroyuki Watanabe, Norio Sawabu |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.medical_specialty Lansoprazole Endoscopic ultrasonography Gastroenterology 2-Pyridinylmethylsulfinylbenzimidazoles Healing rate Internal medicine Gastroscopy medicine Humans In patient Stomach Ulcer Stage (cooking) Aged Ultrasonography Aged 80 and over business.industry Middle Aged Muscle layer Anti-Ulcer Agents Famotidine digestive system diseases Histamine H2 Antagonists Female Famotidine 20 MG business Omeprazole medicine.drug |
| Zdroj: | Journal of Clinical Gastroenterology. 20:S32-S35 |
| ISSN: | 0192-0790 |
| DOI: | 10.1097/00004836-199506002-00009 |
| Popis: | To compare the efficacy of lansoprazole and famotidine in the treatment of gastric ulcer, 24 patients with gastric ulcer were treated for 8 weeks. They were assessed by endoscopic ultrasonography (EUS), which provides cross-sectional images of the gastric wall as well as endoscopic images. Patients were randomly assigned to receive either lansoprazole 30 mg once daily (n = 12), or famotidine 20 mg twice daily (n = 12). The healing rate after 4 weeks of treatment was 80% in the lansoprazole group and 40% in the famotidine group. After 8 weeks of treatment, the respective healing rates were 100 and 72.7%. Healing to Sakita's S 2 stage of scarring occurred significantly more often in the lansoprazole group than in the famotidine group after 4 weeks (50% vs. 0% ; p < 0.05). After 4 weeks of treatment, the submucosal fibrous tissues detected by EUS were significantly less extensive in the lansoprazole-treated patients with deep ulcers (reaching the muscle layer or serosa) than in the famotidine-treated patients with deep ulcers (p < 0.01). These results suggest that lansoprazole may be more effective in ulcer healing than famotidine, particularly in patients with deep gastric ulcers. |
| Databáze: | OpenAIRE |
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