The emerging paradigm of calcium homeostasis as a new therapeutic target for protozoan parasites
| Autor: | Matthew C Weyenberg, Ravi Durvasula, Stefan M. Kanzok, Poonam, Catherine M. Pearce, Neha Sharma, Jesus G Romero, Raman Mathur, Steven Goicoechea, Brijesh Rathi, Prakasha Kempaiah, Yash Gupta, Hoseah M. Akala, Bharathi Daravath, Samuel K. Kwofie |
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| Rok vydání: | 2021 |
| Předmět: |
Drug
media_common.quotation_subject Cryptosporidiosis Cryptosporidium Cellular homeostasis Computational biology Drug resistance Chemical library 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine parasitic diseases Drug Discovery Animals Homeostasis Humans Parasites 030304 developmental biology media_common Pharmacology 0303 health sciences biology fungi Kinetoplastida biology.organism_classification Leishmania chemistry 030220 oncology & carcinogenesis Trypanosoma Molecular Medicine Calcium Function (biology) |
| Zdroj: | Medicinal Research Reviews. 42:56-82 |
| ISSN: | 1098-1128 0198-6325 |
| Popis: | Calcium channels (CCs), a group of ubiquitously expressed membrane proteins, are involved in many pathophysiological processes of protozoan parasites. Our understanding of CCs in cell signaling, organelle function, cellular homeostasis, and cell cycle control has led to improved insights into their structure and functions. In this article, we discuss CCs characteristics of five major protozoan parasites Plasmodium, Leishmania, Toxoplasma, Trypanosoma, and Cryptosporidium. We provide a comprehensive review of current antiparasitic drugs and the potential of using CCs as new therapeutic targets. Interestingly, previous studies have demonstrated that human CC modulators can kill or sensitize parasites to antiparasitic drugs. Still, none of the parasite CCs, pumps, or transporters has been validated as drug targets. Information for this review draws from extensive data mining of genome sequences, chemical library screenings, and drug design studies. Parasitic resistance to currently approved therapeutics is a serious and emerging threat to both disease control and management efforts. In this article, we suggest that the disruption of calcium homeostasis may be an effective approach to develop new anti-parasite drug candidates and reduce parasite resistance. |
| Databáze: | OpenAIRE |
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