Recovery of persistent hypogonadism by clomiphene in males with prolactinomas under dopamine agonist treatment
| Autor: | Julio Abucham, Rogerio Silicani Ribeiro |
|---|---|
| Přispěvatelé: | Universidade Federal de São Paulo (UNIFESP) |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Context (language use) Biology Dopamine agonist Clomiphene Young Adult Endocrinology Erectile Dysfunction Clomifene Internal medicine medicine Humans Pituitary Neoplasms Prolactinoma Testosterone Prospective Studies Sperm motility Estradiol Hypogonadism Estrogen Antagonists Recovery of Function General Medicine Luteinizing Hormone Middle Aged Prostate-Specific Antigen medicine.disease Prolactin Dopamine Agonists Body Composition Sperm Motility Drug Therapy Combination Follicle Stimulating Hormone Energy Metabolism Spermatogenesis medicine.drug |
| Zdroj: | Repositório Institucional da UNIFESP Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
| ISSN: | 1479-683X 0804-4643 |
| Popis: | ContextPersistence of hypogonadism is common in male patients with prolactinomas under dopamine agonist (DA) treatment. Conventional therapy with testosterone causes undesirable fluctuations in serum testosterone levels and inhibition of spermatogenesis.ObjectiveTo evaluate the use of clomiphene as a treatment for persistent hypogonadism in males with prolactinomas.DesignOpen label, single-arm, prospective trial.PatientsFourteen adult hypogonadal males (testosterone InterventionClomiphene (50 mg/day orally) for 12 weeks.MeasuresTestosterone, estradiol, LH, FSH, and prolactin were measured before and 10 days, 4, 8, and 12 weeks after clomiphene. Erectile function, sperm analysis, body composition, and metabolic profiles were evaluated before and after clomiphene.ResultsTen patients (71%), five hyperprolactinemic and two normoprolactinemic, responded to clomiphene (testosterone >300 ng/dl). Testosterone levels increased from 201±22 to 457±37 ng/dl, 436±52, and 440±47 ng/dl at 4, 8, and 12 weeks respectively (0.001 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|