Increased prevalence of pathogenic bacteria in the gut microbiota of infants at risk of developing celiac disease: The PROFICEL study
| Autor: | Luis Ortigosa, Francesc Palau, Amalia Capilla, Carmen Ribes-Koninckx, Vicente Varea, Gemma Castillejo, Ester Donat, Alfonso Benítez-Páez, Esther Nova, Yolanda Sanz, C. Calvo, José Antonio Garrote, Giada De Palma, Ascensión Marcos, Marta Olivares, Isabel Polanco |
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| Přispěvatelé: | Ministerio de Economía y Competitividad (España), European Research Council |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Disease Gut flora medicine.disease_cause Feces 0302 clinical medicine Genotype Celiac disease gut microbiota Enteropathy 2. Zero hunger biology Gastroenterology celiac disease 3. Good health Infectious Diseases HLA genotype PCR 030211 gastroenterology & hepatology Microbiology (medical) Risk Brief Report - Invited Gut microbiota Microbiology 03 medical and health sciences HLA-DQ Antigens medicine Enterotoxigenic Escherichia coli Humans Genetic Predisposition to Disease Clostridium Bacteria Infant Newborn Gluten intolerance Pathogenic bacteria Feeding Behavior Clostridium perfringens medicine.disease biology.organism_classification Gastrointestinal Microbiome 030104 developmental biology Spain Immunology pathogenic bacteria |
| Zdroj: | Gut Microbes r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu Fundació Sant Joan de Déu Digital.CSIC. Repositorio Institucional del CSIC instname Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid Consejería de Sanidad de la Comunidad de Madrid Gut microbes r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu |
| ISSN: | 1949-0976 |
| Popis: | 8 páginas, 1 figura, 2 tablas Celiac disease (CD) is an immune-mediated enteropathy involving genetic and environmental factors, whose interaction influences disease risk. The intestinal microbiota, including viruses and bacteria, could play a role in the pathological process leading to gluten intolerance. In this study, we investigated the prevalence of pathogens in the intestinal microbiota of infants at familial risk of developing CD. We included 127 full-term newborns with at least one first-degree relative with CD. Infants were classified according to milk-feeding practice (breastfeeding or formula feeding) and HLA-DQ genotype (low, intermediate or high genetic risk). The prevalence of pathogenic bacteria and viruses was assessed in the faeces of the infants at 7 days, 1 month and 4 months of age. The prevalence of Clostridium perfringens was higher in formula-fed infants than in breast-fed over the study period, and that of C. difficile at 4 months. Among breastfed infants, a higher prevalence of enterotoxigenic E. coli (ETEC) was found in infants with the highest genetic risk compared either to those with a low or intermediate risk. Among formula-fed infants, a higher prevalence of ETEC was also found in infants with a high genetic risk compared to those of intermediate risk. Our results show that specific factors, such as formula feeding and the HLA-DQ2 genotype, previously linked to a higher risk of developing CD, influence the presence of pathogenic bacteria differently in the intestinal microbiota in early life. Further studies are warranted to establish whether these associations are related to CD onset later in life. This work was supported by grants AGL2011-25169, AGL2014-52101-P and AGL2007-66126-C03-03/ALI (YS and FP) from the Spanish Ministry of Economy and Competitiveness (MINECO). The scholarship to MO from CSIC (JAEpre) and the contract to ABP from the European Union's Seventh Framework Program under the grant agreement no 613979 (MyNewGut) are also fully acknowledged. |
| Databáze: | OpenAIRE |
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