The Importance of Natural Antioxidants in the Treatment of Spinal Cord Injury in Animal Models: An Overview
| Autor: | Sandra Orozco-Suárez, Carlos E. Orozco-Barrios, Christian Guerra-Araiza, Hermelinda Salgado-Ceballos, Juan Manuel Gallardo, Angélica Coyoy-Salgado, Iris A. Feria-Romero, Julia J. Segura-Uribe |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Primates
Aging Antioxidant medicine.medical_treatment Anti-Inflammatory Agents Review Article Bioinformatics medicine.disease_cause Biochemistry Antioxidants Mice Chinese traditional Peroxynitrous Acid medicine Animals In patient Medicine Chinese Traditional lcsh:QH573-671 Spinal cord injury Spinal Cord Injuries chemistry.chemical_classification Reactive oxygen species Mesh term business.industry lcsh:Cytology Cell Biology General Medicine medicine.disease Rats Antioxidant capacity Disease Models Animal Oxidative Stress Neuroprotective Agents chemistry Lipid Peroxidation business Oxidative stress Drugs Chinese Herbal |
| Zdroj: | Oxidative Medicine and Cellular Longevity, Vol 2019 (2019) Oxidative Medicine and Cellular Longevity |
| ISSN: | 1942-0994 1942-0900 |
| Popis: | Patients with spinal cord injury (SCI) face devastating health, social, and financial consequences, as well as their families and caregivers. Reducing the levels of reactive oxygen species (ROS) and oxidative stress are essential strategies for SCI treatment. Some compounds from traditional medicine could be useful to decrease ROS generated after SCI. This review is aimed at highlighting the importance of some natural compounds with antioxidant capacity used in traditional medicine to treat traumatic SCI. An electronic search of published articles describing animal models of SCI treated with natural compounds from traditional medicine was conducted using the following terms: Spinal Cord Injuries (MeSH terms) AND Models, Animal (MeSH terms) AND [Reactive Oxygen Species (MeSH terms) AND/OR Oxidative Stress (MeSH term)] AND Medicine, Traditional (MeSH terms). Articles reported from 2010 to 2018 were included. The results were further screened by title and abstract for studies performed in rats, mice, and nonhuman primates. The effects of these natural compounds are discussed, including their antioxidant, anti-inflammatory, and antiapoptotic properties. Moreover, the antioxidant properties of natural compounds were emphasized since oxidative stress has a fundamental role in the generation and progression of several pathologies of the nervous system. The use of these compounds diminishes toxic effects due to their high antioxidant capacity. These compounds have been tested in animal models with promising results; however, no clinical studies have been conducted in humans. Further research of these natural compounds is crucial to a better understanding of their effects in patients with SCI. |
| Databáze: | OpenAIRE |
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