Cushing's Syndrome Due to an ACTH-producing Neuroendocrine Tumour in the Nasal Roof
| Autor: | Sigbritt Werner, Tore Curstedt, Björn Jacobsson, Lennart Boström, Peter Biberfeld, Adolf Weger |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Hydrocortisone Fulminant Nose Neoplasms Peptide hormone Paraneoplastic Endocrine Syndromes Cushing syndrome Corticotropin-releasing hormone Adrenocorticotropic Hormone Internal medicine Internal Medicine medicine Humans Aldosterone Cushing Syndrome Nose Gastrin S syndrome business.industry Middle Aged medicine.disease Neuroendocrine tumour ACTH Syndrome Ectopic Endocrinology medicine.anatomical_structure business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Acta Medica Scandinavica. 217:235-240 |
| ISSN: | 0001-6101 |
| DOI: | 10.1111/j.0954-6820.1985.tb01662.x |
| Popis: | A patient with ectopic adrenocorticotrophic hormone (ACTH) production from a neuroendocrine tumour of the nasal roof is presented. By indirect immunoperoxidase techniques the tumour cells were shown to be distinctly positive for ACTH and beta-endorphin but negative for other peptides derived from pro-opiomelanocortin. Neither corticotropin releasing hormone (CRF) found in some tumours associated with ectopic Cushing's syndrome, nor gastrin immunoreactivity, which coexists with ACTH in normal rat pituitary and in rat and human gastrointestinal cells, were demonstrable in the tumour. A review of other, previously recognized locations of CRF/ACTH producing tumours is given to increase the awareness of the ectopic Cushing's syndrome, which may lack the classical features and is characterized by fulminant clinical course, extreme fatigue, weakness, pale facial swelling, oedema and hypokalaemic alkalosis. |
| Databáze: | OpenAIRE |
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