Equivalences between refractive index and equilibrium water content of conventional and silicone hydrogel soft contact lenses from automated and manual refractometry
| Autor: | José Manuel González-Méijome, M. Elisabete C.D. Real Oliveira, José B. Almeida, Manuel A. Parafita, Madalena Lira, Antonio López-Alemany |
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| Přispěvatelé: | Universidade do Minho |
| Rok vydání: | 2006 |
| Předmět: |
Materials science
Silicones Refractive index Biomedical Engineering Analytical chemistry Biocompatible Materials 02 engineering and technology Biomaterials 03 medical and health sciences 0302 clinical medicine Refractometer Humans Brix sucrose scale Brix scale CLR 12-70 Water content Soft contact lenses chemistry.chemical_classification Science & Technology Equilibrium water content Water Hydrogels Atago N2E sucrose Polymer Silicone hydrogel conventional soft contact lenses Contact Lenses Hydrophilic 021001 nanoscience & nanotechnology Contact lens Refractometry chemistry Self-healing hydrogels 030221 ophthalmology & optometry 0210 nano-technology |
| Zdroj: | Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| ISSN: | 1552-4981 1552-4973 |
| DOI: | 10.1002/jbm.b.30583 |
| Popis: | PURPOSE: The purpose of the present study was to develop mathematical relationships that allow obtaining equilibrium water content and refractive index of conventional and silicone hydrogel soft contact lenses from refractive index measures obtained with automated refractometry or equilibrium water content measures derived from manual refractometry, respectively. METHODS: Twelve HEMA-based hydrogels of different hydration and four siloxane-based polymers were assayed. A manual refractometer and a digital refractometer were used. Polynomial models obtained from the sucrose curves of equilibrium water content against refractive index and vice-versa were used either considering the whole range of sucrose concentrations (16-100% equilibrium water content) or a range confined to the equilibrium water content of current soft contact lenses ( approximately 20-80% equilibrium water content). RESULTS: Values of equilibrium water content measured with the Atago N-2E and those derived from the refractive index measurement with CLR 12-70 by the applications of sucrose-based models displayed a strong linear correlation (r(2) = 0.978). The same correlations were obtained when the models are applied to obtain refractive index values from the Atago N-2E and compared with those (values) given by the CLR 12-70 (r(2) = 0.978). No significantly different results are obtained between models derived from the whole range of the sucrose solution or the model limited to the normal range of soft contact lens hydration. CONCLUSIONS: Present results will have implications for future experimental and clinical research regarding normal hydration and dehydration experiments with hydrogel polymers, and particularly in the field of contact lenses. This study was supported in part by a grant from the Science and Technology Foundation (FCT) - Ministry of Science and Superior Education (MCES) under contract 8281/2002 from the European Social Funding granted to JMG-M. |
| Databáze: | OpenAIRE |
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