Selective Effect of Fractions of a Yeast Extract (PCO) on Normal and Malignant Cells
| Autor: | Tsuchiya Y, Cook Es, Poydock Me, Fardon Jc |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Mitotic index
Saccharomyces cerevisiae Mitosis Bone Marrow Cells Thymus Gland Chemical Fractionation Cell Line Pathology and Forensic Medicine Cornea Mice Yeast Dried In vivo medicine Animals Yeast extract Molecular Biology Corneal epithelium biology Methanol Neoplasms Experimental Cell Biology General Medicine biology.organism_classification In vitro medicine.anatomical_structure Biochemistry Female Bone marrow |
| Zdroj: | Pathobiology. 46:231-239 |
| ISSN: | 1423-0291 1015-2008 |
| DOI: | 10.1159/000162898 |
| Popis: | The selective action of two fractions of PCO (a yeast extract) on normal and malignant cells was demonstrated. In vivo, the mitotic activity of malignant cells was inhibited by the methanol-insoluble fraction of PCO, whereas the methanol-soluble fraction caused no inhibition. The in vitro studies, however, showed inhibition of mitoses with both fractions. The malignant cells employed in vitro and in vivo were the Krebs-2 and Ehrlich carcinomas. The nonneoplastic cells tested in vitro were established cultures of epithelial-like cells from murine bone marrow and thymus, and corneal epithelium and peripheral blood in vivo. |
| Databáze: | OpenAIRE |
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