Vitamin D levels in an Australian and New Zealand cohort and the association with pregnancy outcome
| Autor: | Luke E. Grzeskowiak, Rebecca L. Wilson, Paul H. Anderson, Jessica A. Grieger, Alison J. Leviton, Gustaaf A. Dekker, Shalem Leemaqz, Claire T. Roberts, Lesley M. E. McCowan, Petra E. Verburg, Tina Bianco-Miotto |
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| Přispěvatelé: | Wilson, Rebecca L, Leviton, Alison J, Leemaqz, Shalem Y, Anderson, Paul H, Grieger, Jessica A, Grzeskowiak, Luke E, Verburg, Petra E, McCowan, Lesley, Dekker, Gustaaf A, Bianco-Miotto, Tina, Roberts, Claire T |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
vitamin D Gestational diabetes mellitus 0302 clinical medicine Pregnancy Medicine 030212 general & internal medicine Prospective Studies Vitamin D POSITION STATEMENT Prospective cohort study 2. Zero hunger RISK Obstetrics Obstetrics and Gynecology WOMEN GESTATIONAL DIABETES-MELLITUS gestational diabetes mellitus 3. Good health PREECLAMPSIA fetal sex Cohort Infant Small for Gestational Age Gestation Premature Birth Female pregnancy Research Article Adult medicine.medical_specialty D SUPPLEMENTATION Adolescent Reproductive medicine BODY-FAT 030209 endocrinology & metabolism Gestational Age lcsh:Gynecology and obstetrics vitamin D deficiency Pregnancy outcome Preeclampsia 03 medical and health sciences Young Adult D DEFICIENCY Sex Factors Vitamin D and neurology Humans D METABOLISM lcsh:RG1-991 pregnancy outcome business.industry Fetal sex Australia Infant Newborn Protective Factors medicine.disease Vitamin D Deficiency Diabetes Gestational SERUM 25-HYDROXYVITAMIN D business New Zealand |
| Zdroj: | BMC Pregnancy and Childbirth, 18:251. BMC BMC Pregnancy and Childbirth BMC Pregnancy and Childbirth, Vol 18, Iss 1, Pp 1-10 (2018) |
| ISSN: | 1471-2393 |
| Popis: | Background Pregnant women are at increased susceptibility to vitamin D deficiency. Hence, there is continuing interest in determining how vitamin D influences pregnancy health. We aimed to compare vitamin D status in two distinct populations of pregnant women in Australia and New Zealand and to investigate the relationship between vitamin D status and pregnancy outcome. This included evaluating possible effect measure modifications according to fetal sex. Methods Serum 25-hydroxy vitamin D (25(OH)D) was measured at 15 ± 1 weeks’ gestation in 2800 women from Adelaide and Auckland who participated in the multi-centre, prospective cohort SCreening fOr Pregnancy Endpoints (SCOPE) study. Results Mean serum 25(OH)D in all women was 68.1 ± 27.1 nmol/L and 28% (n = 772) were considered vitamin D deficient ( 81 nmol/L) “standardised” vitamin D status when compared to moderate-high (63–81 nmol/L, aRR, 0.47; 95% CI: 0.23, 0.96). Marginal sex-specific differences occurred between vitamin D status and GDM: women carrying a female fetus had a 56% decreased risk for GDM in those with low-moderate levels of standardised vitamin D (44–63 nmol/L) compared to moderate-high levels (aRR: 0.44; 95% CI: 0.20, 0.97), whilst in women carrying a male fetus, a 55% decreased risk of GDM was found with high standardised vitamin D when compared to moderately-high vitamin D, but this was not statistically significant (aRR: 0.45; 95% CI: 0.15, 1.38). Conclusions High serum 25(OH)D at 15 ± 1 weeks’ gestation was shown to be protective against the development of GDM. A possible association between fetal sex, vitamin D status and GDM provides further questions and encourages continual research and discussion into the role of vitamin D in pregnancy, particularly in vitamin D replete populations. Electronic supplementary material The online version of this article (10.1186/s12884-018-1887-x) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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