Diversity-Oriented Synthesis of Steviol Glycosides
| Autor: | Jing-Jing Sui, Qiao Zhi, Richard R. Schmidt, Yuan-Hong Tu, Jin-Xi Liao, Jian-Song Sun, Hui Liu |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
Models Molecular animal structures Glycosylation 010405 organic chemistry Chemistry Organic Chemistry Glycoside Steviol Chemistry Techniques Synthetic 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences carbohydrates (lipids) chemistry.chemical_compound Carbohydrate Conformation lipids (amino acids peptides and proteins) Carbohydrate conformation Glycosides Diterpenes Kaurane |
| Zdroj: | The Journal of organic chemistry. 83(19) |
| ISSN: | 1520-6904 |
| Popis: | With cheap and easily available mixtures of steviol glycosides as starting materials, a practical method for steviol acquisition has been developed, on the basis of which a facile, diversity-oriented, and economic protocol for the synthesis of structurally defined steviol glycosides was established. The novel approach is featured by the highly efficient glycosylation of sterically hindered and acid-sensitive steviol via orchestrated application of Yu glycosylation, Schmidt glycosylation, and PTC glycosylation. Hence, these high-intensity sweeteners and potential lead compounds for drug development are now readily accessible. |
| Databáze: | OpenAIRE |
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