Performance of 111In-labelled PSMA ligand in patients with nodal metastatic prostate cancer: correlation between tracer uptake and histopathology from lymphadenectomy
| Autor: | Vanessa Drendel, Philipp T. Meyer, Wolfgang Schultze-Seemann, Michael Mix, Cordula A. Jilg, Kathrin Reichel, C. Stoykow, Eleni Gourni, Mark Bartholomä, Ulrich Wetterauer |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Receiver operating characteristic business.industry medicine.medical_treatment 030232 urology & nephrology Area under the curve 610 Medicine & health General Medicine urologic and male genital diseases 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Isotopes of gallium Prostate 030220 oncology & carcinogenesis medicine Radiology Nuclear Medicine and imaging Lymphadenectomy Histopathology Nuclear medicine business Lymph node Gamma probe |
| Zdroj: | Mix, Michael; Reichel, Kathrin; Stoykow, Christian; Bartholomä, Mark; Drendel, Vanessa; Gourni, Eleni; Wetterauer, Ulrich; Schultze-Seemann, Wolfgang; Meyer, Philipp T.; Jilg, Cordula A. (2018). Performance of 111In-labelled PSMA ligand in patients with nodal metastatic prostate cancer: correlation between tracer uptake and histopathology from lymphadenectomy. European journal of nuclear medicine and molecular imaging, 45(12), pp. 2062-2070. Springer-Verlag 10.1007/s00259-018-4094-0 |
| DOI: | 10.7892/boris.125643 |
| Popis: | PURPOSE: Intraoperative identification of lymph node (LN) metastases (LNM) detected on preoperative PSMA PET/CT may be facilitated by PSMA radioguided surgery with the use of a gamma probe. We evaluated the uptake of 111In-labelled PSMA ligand DKFZ-617 (referred to as 111In-PSMA-617) in unaffected LN and LNM at the level of single LN. METHODS: Six patients with prostate cancer (PCa) with suspicion of LNM on preoperative PSMA PET/CT underwent 111In-PSMA-617-guided lymphadenectomy (LA; four salvage LA and two primary LA). 111In-PSMA-617 (109 ± 5 MBq). was injected Intravenously 48 h prior to surgery Template LAs were performed in small subregions: common, external, obturator and internal iliac vessels, and presacral and retroperitoneal subregions (n = 4). Samples from each subregion were isolated aiming at the level of single LN. Uptake was measured ex situ using a germanium detector. Receiver operating characteristic (ROC) analysis was performed based on 111In-PSMA-617 uptake expressed as standardized uptake values normalized to lean body mass (SUL). RESULTS: Overall 310 LN (mean 52 ± 19.7) were removed from 74 subregions (mean 12 ± 3.7). Of the 310 LN, 35 turned out to be LNM on histopathology. Separation of the samples from all subregions resulted in 318 single specimens: 182 PCa-negative LN samples with 275 LN, 35 single LNM samples, 3 non-nodal PCa tissue samples and 98 fibrofatty tissue samples. The median SULs of nonaffected LN (0.16) and affected LN (13.2) were significantly different (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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