A comparative prospective study of a chronic low dose versus a conventional ovulation stimulation regimen using recombinant human follicle stimulating hormone in anovulatory infertile women
| Autor: | B. Hedon, D. Barbereau, A. Boujenah, J.C. Emperaire, Jean-Noël Hugues, J.J. Chabaud, C.M. Howles, F. Truong |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
medicine.medical_specialty media_common.quotation_subject medicine.medical_treatment Drug Resistance Ovarian hyperstimulation syndrome Biology Clomiphene Anovulation Follicle-stimulating hormone Ovarian Hyperstimulation Syndrome Ovarian Follicle Ovulation Induction Pregnancy Internal medicine medicine Humans Prospective Studies Ovarian follicle Ovulation media_common Rehabilitation Obstetrics and Gynecology medicine.disease Recombinant Proteins Regimen Pregnancy rate Endocrinology medicine.anatomical_structure Reproductive Medicine Ovulation induction Female Follicle Stimulating Hormone Safety Infertility Female |
| Zdroj: | Human reproduction (Oxford, England). 13(1O) |
| ISSN: | 0268-1161 |
| Popis: | The efficacy and safety of a chronic low dose (group A) and a conventional (group B) stimulation regimen of recombinant human follicle stimulating hormone (r-HFSH) were compared in 103 WHO Group II infertile women with clomiphene citrate-resistant anovulation. Mono- or bifollicular development was induced in 88.1% of patients in group A compared with 76.1% in group B. Ovulation and pregnancy rates were higher in group A (71.4% and 33.3%, respectively) than in group B (63.0% and 20%), but these differences were not statistically significant. Additionally, the total number of follicles that were >10 mm diameter was lower in group A than group B (3.0+/-2.6 versus 6.3+/-6.5; P < 0.0001), as was the oestradiol concentration (504+/-477 pg/ml versus 988+/-740 pg/ml; P < 0.03). The median dose of FSH (75 IU ampoules) used per cycle was 11 ampoules in group A and 12.5 in group B. In terms of the incidence of ovarian hyperstimulation syndrome, no differences were recorded between the two groups. The results demonstrated that r-HFSH is effective and safe in both these treatment protocols. The chronic low dose regimen was associated with a trend towards a higher rate of mono- or bifollicular development, without jeopardizing the incidence of pregnancy. |
| Databáze: | OpenAIRE |
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