The Incidence and Impact of In-Hospital Bleeding in Patients with Acute Coronary Syndrome during the COVID-19 Pandemic

Autor: Roberto Licordari, Alessandro Sticchi, Filippo Mancuso, Alessandro Caracciolo, Saverio Muscoli, Fortunato Iacovelli, Rossella Ruggiero, Alessandra Scoccia, Valeria Cammalleri, Marco Pavani, Marco Loffi, Domenico Scordino, Jayme Ferro, Andrea Rognoni, Andrea Buono, Stefano Nava, Stefano Albani, Iginio Colaiori, Filippo Zilio, Marco Borghesi, Valentina Regazzoni, Stefano Benenati, Fabio Pescetelli, Vincenzo De Marzo, Antonia Mannarini, Francesco Spione, Doronzo Baldassarre, Michele De Benedictis, Roberto Bonmassari, Gian Battista Danzi, Mario Galli, Alfonso Ielasi, Giuseppe Musumeci, Fabrizio Tomai, Vincenzo Pasceri, Italo Porto, Giuseppe Patti, Gianluca Campo, Antonio Colombo, Antonio Micari, Francesco Giannini, Francesco Costa
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of Clinical Medicine; Volume 11; Issue 10; Pages: 2926
ISSN: 2077-0383
DOI: 10.3390/jcm11102926
Popis: Background: The COVID-19 pandemic increased the complexity of the clinical management and pharmacological treatment of patients presenting with an Acute Coronary Syndrome (ACS). Aim: to explore the incidence and prognostic impact of in-hospital bleeding in patients presenting with ACS before and during the COVID-19 pandemic. Methods: We evaluated in-hospital Thrombolysis In Myocardial Infarction (TIMI) major and minor bleeding among 2851 patients with ACS from 17 Italian centers during the first wave of the COVID-19 pandemic (i.e., March–April 2020) and in the same period in the previous two years. Results: The incidence of in-hospital TIMI major and minor bleeding was similar before and during the COVID-19 pandemic. TIMI major or minor bleeding was associated with a significant threefold increase in all-cause mortality, with a similar prognostic impact before and during the COVID-19 pandemic. Conclusions: the incidence and clinical impact of in-hospital bleeding in ACS patients was similar before and during the COVID-19 pandemic. We confirmed a significant and sizable negative prognostic impact of in-hospital bleeding in ACS patients.
Databáze: OpenAIRE
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