The significance of tumour markers as an indication for mediastinoscopy in non-small cell lung cancer
| Autor: | Masayuki Shima, Hideki Kimura, Michiko Ando, Naomichi Iwai, Soichiro Ando, Kimitaka Kakizawa |
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| Rok vydání: | 2003 |
| Předmět: |
Pulmonary and Respiratory Medicine
Oncology Male medicine.medical_specialty Multivariate analysis Lung Neoplasms endocrine system diseases N2 disease Mediastinoscopy Internal medicine Carcinoma Non-Small-Cell Lung medicine Carcinoma Biomarkers Tumor Humans Lung cancer neoplasms Aged Retrospective Studies Lung medicine.diagnostic_test business.industry Cancer Middle Aged medicine.disease Carcinoembryonic Antigen medicine.anatomical_structure Thoracotomy Lymphatic Metastasis Multivariate Analysis Female Non small cell business |
| Zdroj: | Respirology (Carlton, Vic.). 8(2) |
| ISSN: | 1323-7799 |
| Popis: | Objective: The purpose of this study was to verify the significance of tumour markers as indicators for mediastinoscopy in non-small cell lung cancer. Methodology: In the past 4 years, 205 patients with non-small cell lung carcinoma (NSCLC) underwent surgical resection at Chiba Cancer Center, Chiba, Japan. The correlation between the serum levels of eight tumour markers (CEA, AFP, CA19-9, SCC, NSE, CA125, CYFRA, ProGRP) and the presence of N2 disease was analysed. Univariate and multivariate analyses were performed to determine the relationship between both marker levels and clinical findings and N2 disease. Results: In multivariate analysis, positive CEA was significantly associated with the diagnosis of N2 disease. We also demonstrated that when CA125, CYFRA and ProGRP were positive, they were individually significantly associated with N2 disease. However, CEA was superior to the other markers and equivalent to a combination of various tumour markers. Conclusion: It was concluded that evaluation of CEA in addition to CT is of use in the diagnosis of N2 disease in NSCLC patients and should be used as an indication for mediastinoscopy. |
| Databáze: | OpenAIRE |
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