Predictors of common femoral artery access site complications in patients on oral anticoagulants and undergoing a coronary procedure
Autor: | W John Shammas, Nicolas W. Shammas, Majid Z. Chammas, Susan Jones-Miller, Rommy Khalafallah, Andrew N. Shammas, Amy Barzgari, Mileah Rose Gumpert, Christine Harb, Bassel Bou Dargham, Ghassan Daher, Miranda Jade Gumpert, Rayan Jo Rachwan, Gail A. Shammas |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
medicine.medical_specialty
complications Therapeutics and Clinical Risk Management Femoral artery Group B 03 medical and health sciences 0302 clinical medicine oral anticoagulant medicine.artery Clinical endpoint Medicine Pharmacology (medical) In patient 030212 general & internal medicine General Pharmacology Toxicology and Pharmaceutics Adverse effect Original Research Chemical Health and Safety 030504 nursing business.industry General Medicine Odds ratio access site Surgery common femoral artery Access site Underweight medicine.symptom 0305 other medical science business Safety Research |
Zdroj: | Therapeutics and Clinical Risk Management |
ISSN: | 1178-203X |
Popis: | Nicolas W Shammas,1,2 Gail A Shammas,1 Susan Jones-Miller,1,2 Mileah Rose Gumpert,1 Miranda Jade Gumpert,1 Christine Harb,1 Majid Z Chammas,1 W John Shammas,1 Rommy A Khalafallah,1 Amy Barzgari,1 Bassel Bou Dargham,1 Ghassan E Daher,1 Rayan Jo Rachwan,1 Andrew N Shammas1 1Midwest Cardiovascular Research Foundation, 2Cardiology Division, Genesis Heart Institute, Davenport, IA, USA Background: It is unclear whether patients on oral anticoagulants (OAC) undergoing a procedure using common femoral artery access have higher adverse events when compared to patients who are not anticoagulated at the time of the procedure.Methods: We retrospectively reviewed data from consecutive patients who underwent a cardiac procedure at a tertiary medical center. Patients were considered (group A) fully or partially anticoagulated if they had an international normalized ratio (INR) ≥1.6 on the day of the procedure or were on warfarin or new OAC within 48h and 24h of the procedure, respectively. The nonanticoagulated group (group B) had an INR 48h and >24h preprocedure, respectively. The index primary end point of the study was defined as the composite end point of major bleeding, vascular complications, or cardiovascular-related death during index hospitalization. The 30-day primary end point was defined as the occurrence of the index primary end point and up to 30days postprocedure.Results: A total of 779 patients were included in this study. Of these patients, 27 (3.5%) patients were in group A. The index primary end point was met in 11/779 (1.4%) patients. The 30-day primary composite end point was met in 18/779 (2.3%) patients. There was no difference in the primary end point at index between group A (1/27 [3.7%]) and group B (10/752 [1.3%]; P=0.3155) and no difference in the 30-day primary composite end point between group A (2/27 [7.4%]) and group B (16/752 [2.1%]; P=0.1313). Multivariable analysis showed that a low creatinine clearance (odds ratio [OR] =0.56; P=0.0200) and underweight patients ( |
Databáze: | OpenAIRE |
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