Structural and molecular perspectives of SARS-CoV-2
| Autor: | Kumar, Swatantra, van Regenmortel, Marc H.V., Rivas, Ariel L., Saxena, Shailendra K |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Coronavirus disease 2019 (COVID-19)
viruses Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ACE2 Biology Virus Replication TMPRSS2 Article Protein Structure Secondary General Biochemistry Genetics and Molecular Biology Cellular mechanism 03 medical and health sciences Animals Humans Viral rna Nucleocapsid skin and connective tissue diseases Molecular Biology 030304 developmental biology chemistry.chemical_classification Serine protease 0303 health sciences Binding Sites SARS-CoV-2 fungi 030302 biochemistry & molecular biology COVID-19 virus diseases Cellular receptor Virus Internalization Virology body regions chemistry Spike Glycoprotein Coronavirus Spike-glycoprotein biology.protein Glycoprotein Mpro nsp10/nsp16 2′-O-methylase |
| Zdroj: | Methods (San Diego, Calif.) |
| ISSN: | 1046-2023 |
| DOI: | 10.1016/j.ymeth.2021.03.007 |
| Popis: | Recent emergence of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transpired into pandemic coronavirus disease 2019 (COVID-19). SARS-CoV-2 has been rapidly transmitted across the globe within a short period of time, with more than 106 million cases and 2.3 million deaths. The continuous rise in worldwide cases of COVID-19, transmission dynamics of SARS-CoV-2 including re-infections and enormous case-fatality rates emphasizes the urgent need of potential preventive and therapeutic measures. The development of effective therapeutic and preventive measures relies on understanding the molecular and cellular mechanism of replication exhibited by SARS-CoV-2. The structure of SARS-CoV-2 is ranging from 90/120 nm that comprises surface viral proteins including spike, envelope, membrane which are attached in host lipid bilayer containing the helical nucleocapsid comprising viral RNA. Spike (S) glycoprotein initiates the attachment of SARS-CoV-2 with a widely expressed cellular receptor angiotensin-converting enzyme 2 (ACE2), and subsequent S glycoprotein priming via serine protease TMPRSS2. Prominently, comprehensive analysis of structural insights into the crucial SARS-CoV-2 proteins may lead us to design effective therapeutics molecules. In the present article, we will emphasize the mechanistic insights of SARS-CoV-2 replication including insights into the structural perspective of crucial SARS-CoV-2 proteins. |
| Databáze: | OpenAIRE |
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