Individualized surgery combined with radiotherapy and triamcinolone acetonide injection for the treatment of auricular keloids
| Autor: | You Zhou, Kaijian Zhou, Er-te Yu, Qiang Sun, Shuang Tong, Shu Guo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Scar Excision
medicine.medical_specialty Triamcinolone acetonide RD1-811 medicine.medical_treatment Postoperative radiotherapy TRIAMCINOLONE ACETONIDE INJECTION 030207 dermatology & venereal diseases 03 medical and health sciences Auricular keloid 0302 clinical medicine Keloid Recurrence medicine Humans skin and connective tissue diseases Individualized surgery Radiotherapy business.industry Research Therapeutic effect General Medicine medicine.disease Combined Modality Therapy Surgery Radiation therapy Treatment Outcome 030220 oncology & carcinogenesis Total dose business medicine.drug |
| Zdroj: | BMC Surgery, Vol 21, Iss 1, Pp 1-7 (2021) BMC Surgery |
| ISSN: | 1471-2482 |
| Popis: | Background Although multiple methods have been proposed to treat auricular keloids, low curative effects and high recurrence rates are currently major clinical problems. Thereinto, surgery combined with radiotherapy and triamcinolone acetonide injection is considered to be the proper choice for comprehensive treatment of auricular keloids. This study aimed at evaluating the therapeutic effect of individualized surgery combined with radiotherapy for the treatment of auricular keloids. Methods From February 2014 to February 2017, 67 patients with 113 auricular keloids in total were enrolled in this study. According to specific conditions of lesions, the local tissue and patients’ individual wishes, different surgical methods were selected to analyze the scar excision and repairment of the defect. Within 24 h after the keloid was excised, 5 MeV electron beam irradiation by the linear accelerator was used by radiotherapy with a total dose of 20 Gy at interval of 1 day for 10 consecutive times. Triamcinolone acetonide was injected immediately after surgery, and per month afterward in the following three months. Results 113 keloids in total were received treatment. The follow-up period was 24 months. Fourteen keloids (12.39%) showed subjective recurrence with a success rate of 87.61%. Wilcoxon matched-pairs rank-sum test was used to compare the differences of the 24-month postoperative VSS scores and the preoperative VSS scores. The VSS scores were as follows: 82 keloids (72.57%) scored less than 5 points (good result), 21 keloids (18.58%) scored 6 to 10 points (fair result), and only 10 keloids (8.85%) scored more than 10 points (bad result). The effective rate was 91.15%. Conclusions Individualized surgery combined with early postoperative radiotherapy and triamcinolone acetonide injection is an ideal treatment method to ensure good auricular appearance, low incidences of complications and recurrence based on effective treatment of auricular keloids. |
| Databáze: | OpenAIRE |
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