Repeated Daclizumab Administration to Delay the Introduction of Calcineurin Inhibitors in Heart Transplant Patients With Postoperative Renal Dysfunction
| Autor: | Jaime Agüero Ramón-Llin, Luis Martínez Dolz, Ignacio Sánchez Lázaro, Antonio Salvador Sanz, Luis Almenar Bonet, Josep Navarro Manchón, Francisco Buendía Fuentes, José Luis Vicente Sánchez |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Daclizumab Time Factors medicine.drug_class medicine.medical_treatment Calcineurin Inhibitors Urology Renal function Antibodies Monoclonal Humanized urologic and male genital diseases Therapeutic approach Postoperative Complications medicine Humans Heart transplantation business.industry Acute postoperative renal failure Antibodies Monoclonal General Medicine Acute Kidney Injury Middle Aged Receptor antagonist Surgery Calcineurin Immunoglobulin G Heart Transplantation Female Transplant patient business Immunosuppressive Agents medicine.drug |
| Zdroj: | Revista Española de Cardiología (English Edition). 64:237-239 |
| ISSN: | 1885-5857 |
| DOI: | 10.1016/j.rec.2010.05.001 |
| Popis: | Daclizumab is an interleukin-2 receptor antagonist which is used for induction therapy in heart transplant patients. It has few side effects and is associated with a low infection rate. Postoperative renal failure after heart transplantation is common and potentially fatal. The administration of calcineurin inhibitors in the postoperative period can aggravate the situation. We report the cases of six patients who underwent heart transplantation and developed acute renal failure in the immediate postoperative period. All were administered daclizumab weekly to avoid the introduction of calcineurin inhibitors and to facilitate recovery of renal function. Calcineurin inhibitors were introduced only once renal function had improved. Renal function recovered in all cases and there was a low complication rate. The administration of repeated doses of daclizumab to patients who experience acute postoperative renal failure after heart transplantation may provide an alternative therapeutic approach that enables calcineurin inhibitors to be avoided and, consequently, renal function to recover. |
| Databáze: | OpenAIRE |
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