Anti-cholinesterase activity of lycopodium alkaloids from Vietnamese Huperzia squarrosa (Forst.) Trevis
Autor: | Tran Cong Luan, Tran Manh Hung, Nguyen Ngoc Chuong, Nguyen Thi Thu Huong |
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Rok vydání: | 2014 |
Předmět: |
Lycopodium
Stereochemistry Metabolite Pharmaceutical Science Article Analytical Chemistry lcsh:QD241-441 chemistry.chemical_compound Inhibitory Concentration 50 Alkaloids lcsh:Organic chemistry Drug Discovery medicine Lycopodiaceae Lycopodium alkaloids Physical and Theoretical Chemistry IC50 Huperzine A Cholinesterase biology Traditional medicine Chemistry Plant Extracts Huperzia squarrosa Organic Chemistry Huperzia acetylcholinesterase biology.organism_classification Acetylcholinesterase lycosquarosine A Terpenoid Chemistry (miscellaneous) biology.protein Molecular Medicine Cholinesterase Inhibitors Sesquiterpenes medicine.drug |
Zdroj: | Molecules Volume 19 Issue 11 Pages 19172-19179 Molecules, Vol 19, Iss 11, Pp 19172-19179 (2014) |
ISSN: | 1420-3049 |
Popis: | A series of Lycopodium alkaloids, namely lycosquarosine A (1), acetylaposerratinine (2), huperzine A (3), huperzine B (4), 8α-hydrophlemariurine B (5), and huperzinine (6), has been isolated from Vietnamese Huperzia squarrosa. Among them, lycosquarosine A (1) is the new metabolite of the natural source. Lycosquarosine A completely inhibited AChE activity in a dose dependent manner with an IC50 value of 54.3 μg/mL, while acetylaposerratinine (2) showed stronger inhibitory activity than 1 with an IC50 value of 15.2 µg/mL. This result indicates that these alkaloids may be a potent source of AChE inhibitors. |
Databáze: | OpenAIRE |
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