Anti-cholinesterase activity of lycopodium alkaloids from Vietnamese Huperzia squarrosa (Forst.) Trevis

Autor: Tran Cong Luan, Tran Manh Hung, Nguyen Ngoc Chuong, Nguyen Thi Thu Huong
Rok vydání: 2014
Předmět:
Zdroj: Molecules
Volume 19
Issue 11
Pages 19172-19179
Molecules, Vol 19, Iss 11, Pp 19172-19179 (2014)
ISSN: 1420-3049
Popis: A series of Lycopodium alkaloids, namely lycosquarosine A (1), acetylaposerratinine (2), huperzine A (3), huperzine B (4), 8α-hydrophlemariurine B (5), and huperzinine (6), has been isolated from Vietnamese Huperzia squarrosa. Among them, lycosquarosine A (1) is the new metabolite of the natural source. Lycosquarosine A completely inhibited AChE activity in a dose dependent manner with an IC50 value of 54.3 μg/mL, while acetylaposerratinine (2) showed stronger inhibitory activity than 1 with an IC50 value of 15.2 µg/mL. This result indicates that these alkaloids may be a potent source of AChE inhibitors.
Databáze: OpenAIRE