Short course pre-operative ferrous sulphate supplementation – is it worthwhile in patients with colorectal cancer?
| Autor: | Fiona Ross, Juliette Murray, Martha Quinn, Angus Macdonald, John Murphy, Robert J Drummond |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Anemia Colorectal cancer Administration Oral Preoperative care Drug Administration Schedule Cohort Studies Hemoglobins Internal medicine Preoperative Care medicine Humans Short course In patient Hematinic Ferrous Compounds Aged Aged 80 and over Anemia Iron-Deficiency business.industry General Medicine Middle Aged medicine.disease Surgery Clinical trial Treatment Outcome Hematinics Female business Colorectal Neoplasms Colorectal Surgery Cohort study |
| Popis: | INTRODUCTION Pre-operative anaemia is well recognised in patients presenting with colorectal cancer (CRC). While the benefits of long-term FeSO4 supplementation on Fe deficiency anaemia are well established, it is not known if short-course supplementation (2–3 weeks) impacts significantly on pre-operative haemoglobin (Hb) levels. This study examines the impact of short-term, oral FeSO4 supplementation on patients undergoing surgery for CRC. PATIENTS AND METHODS All patients with CRC presenting to a single surgeon were included. At diagnosis, baseline Hb and blood film were checked on all patients who then received 200 mg tds of FeSO4. Haemoglobin was rechecked pre-operatively and daily postoperatively. Patients requiring pre-operative blood transfusions were excluded from analysis. RESULTS Between 1 January 2004 and 31 December 2006, 117 patients were identified, 14 of whom were excluded. Patients received a median of 39 days’ treatment with FeSO4. Fifty-eight (56.3%) patients were anaemic at presentation gaining a mean of 1.73 g/dl (P < 0.001) from short-course FeSO4 supplementation. Right-sided tumours (lower mean Hb at presentation; P = 0.008) responded more to FeSO4 when compared to left-sided tumours (P < 0.017). Increase in Hb was unrelated to pathological stage. The transfusion rate for all curative resections was 0.69 units/patient. For the historical cohort (patients undergoing curative resection between 1 January 2001 and 31 December 2003), the mean transfusion rate fell from 1.69 units/patient. CONCLUSIONS Routine short-course supplementation with iron offers improved pre-operative Hb prior to surgery in CRC, especially in right-sided lesions and those with presenting anaemia. |
| Databáze: | OpenAIRE |
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