Impact of Serum Vancomycin Trough Levels in the Treatment of Central Nervous System Shunt Infections Caused by Coagulase-Negative Staphylococci

Autor:	Sheldon L. Kaplan, Jesus G. Vallejo, Ashley Gibson
Rok vydání:	2018
Předmět:	0301 basic medicine Central Nervous System Coagulase Male medicine.medical_specialty Adolescent Staphylococcus 030106 microbiology Central nervous system 03 medical and health sciences 0302 clinical medicine Vancomycin Internal medicine medicine Ventriculitis Humans 030212 general & internal medicine Child Adult patients business.industry cons Infant Newborn Infant General Medicine Staphylococcal Infections medicine.disease Cerebrospinal Fluid Shunts Shunt (medical) Anti-Bacterial Agents medicine.anatomical_structure Treatment Outcome Child Preschool Pediatrics Perinatology and Child Health Surgery Female sense organs Neurology (clinical) business Meningitis medicine.drug
Zdroj:	Pediatric neurosurgery. 53(4)
ISSN:	1423-0305
Popis:	Coagulase-negative staphylococci (CoNS) are a common cause of pediatric ventricular shunt infections. The Infectious Diseases Society of America recommends vancomycin serum troughs of 15–20 µg/mL when treating CoNS shunt infections in adult patients. We report a series of pediatric cases of CoNS shunt infections in which clinical cure was obtained with troughs < 15 µg/mL. These findings question the relevance of this recommendation in pediatric patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dd3142086fac3664c7793d868fcb8c5 https://pubmed.ncbi.nlm.nih.gov/29698961 Zobrazit plný text záznamu