Circulating Long Noncoding RNA Signatures Associate With Incident Diabetes in Older Adults: A Prospective Analysis From the VITA Cohort Study
| Autor: | Wenzl, Florian A, Mengozzi, Alessandro, Mohammed, Shafeeq A, Pugliese, Nicola Riccardo, Mongelli, Alessia, Gorica, Era, Ambrosini, Samuele, Riederer, Peter, Fischer, Peter, Hinterberger, Margareta, Puspitasari, Yustina, Lüscher, Thomas F, Camici, Giovanni G, Matter, Christian M, Fadini, Gian Paolo, Virdis, Agostino, Masi, Stefano, Ruschitzka, Frank, Grünblatt, Edna, Paneni, Francesco, Costantino, Sarah |
|---|---|
| Přispěvatelé: | University of Zurich, Paneni, Francesco, Costantino, Sarah |
| Rok vydání: | 2023 |
| Předmět: |
Advanced and Specialized Nursing
2902 Advanced and Specialized Nursing Endocrinology Diabetes and Metabolism 610 Medicine & health 10058 Department of Child and Adolescent Psychiatry Internal Medicine 11459 Center for Molecular Cardiology Diabetes and Metabolism 2712 Endocrinology Diabetes and Metabolism Endocrinology 2724 Internal Medicine 10076 Center for Integrative Human Physiology 10209 Clinic for Cardiology 10064 Neuroscience Center Zurich |
| Zdroj: | Diabetes Care. 46:1239-1244 |
| ISSN: | 1935-5548 0149-5992 |
| Popis: | OBJECTIVE Long noncoding RNAs (lncRNAs) are involved in diabetogenesis in experimental models, yet their role in humans is unclear. We investigated whether circulating lncRNAs associate with incident type 2 diabetes in older adults. RESEARCH DESIGN AND METHODS A preselected panel of lncRNAs was measured in serum of individuals without diabetes (n = 296) from the Vienna Transdanube Aging study, a prospective community-based cohort study. Participants were followed up over 7.5 years. A second cohort of individuals with and without type 2 diabetes (n = 90) was used to validate our findings. RESULTS Four lncRNAs (ANRIL, MIAT, RNCR3, and PLUTO) were associated with incident type 2 diabetes and linked to hemoglobin A1c trajectories throughout the 7.5-year follow-up. Similar results (for MIAT and PLUTO also in combined analysis) were obtained in the validation cohort. CONCLUSIONS We found a set of circulating lncRNAs that independently portends incident type 2 diabetes in older adults years before disease onset. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|