Partial sleep deprivation reduces natural killer cell activity in humans
Autor: | A Mascovich, J C Gillin, T. L. Smith, Jennifer Pike, Michael R. Irwin, R Willoughby |
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Rok vydání: | 1994 |
Předmět: |
Adult
Male medicine.medical_specialty Polysomnography Sleep REM Electroencephalography Immune system Internal medicine medicine Humans Lymphocytes Applied Psychology Immunity Cellular Sleep disorder Sleep Stages medicine.diagnostic_test business.industry Middle Aged medicine.disease Sleep in non-human animals Killer Cells Natural Psychiatry and Mental health Sleep deprivation Endocrinology Mood Sleep Deprivation medicine.symptom business Stress Psychological |
Zdroj: | Scopus-Elsevier |
ISSN: | 0033-3174 |
Popis: | Sleep disturbance, measured by either subjective report or electroencephalographic (EEG) assessment of sleep, correlates with a reduction of natural killer (NK) cell activity in major depression. To test whether sleep loss independent of mood disturbance alters daytime values of cellular immune function, the effect of late-night partial sleep deprivation on NK cell activity was studied in 23 medically and psychiatrically healthy male volunteers. After a night of sleep deprivation between 3 and 7 AM, NK cell activity was reduced in 18 of the 23 subjects with average lytic activity reduced significantly (p < .01) to a level 72% of the mean of three separate baseline values. After a night of resumed nocturnal sleep, NK cell activity had returned to baseline levels. These data implicate sleep in the modulation of natural immunity and demonstrate that even modest disturbances of sleep produce a reduction of NK cell activity. |
Databáze: | OpenAIRE |
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